-48%

GHRP-6 5 mg

Original price was: 24,99 €.Current price is: 12,99 €. with VAT

GHRP-6 was one of the first synthetic GH secretagogues ever developed and remains one of the most extensively studied peptides in this class in preclinical research. It combines a potent GH-releasing effect with significant activation of the ghrelin receptor GHS-R1a—which is relevant to research on metabolism and appetite.

Purity ≥ 98% – Each batch verified by HPLC; COA available upon request
5 mg of lyophilized powder; store at −20 °C
Shipped within 48 hours

In stock

Dosage calculator

Quantity discount

Quantity	Price	% Discount
7+	11,69 €	10%
4+	12,34 €	5%

Category: Research on muscle growth Tags: Fitness & Bodybuilding, GHRP-6

All products are sold exclusively for the purpose of scientific research and development.
The chemical substances may not be used as a medicine, drug, active substance, medical device, cosmetic product, substance for the manufacture of a cosmetic product, or as a substance for human consumption, i.e. as a food or nutritional supplement, or in any other similar way on humans or animals.

All customers MUST be at least 18 years of age to purchase our products.

Laboratory-tested

Fast and Discreet Shipping

Purity Guarantee

98%+

Description

H1: GHRP-6 5 mg – Ghrelin Receptor Agonist for Research on GH Secretion

⚠️ Warning: GHRP-6 sold on jacked.sk is intended exclusively for scientific research purposes (research use only). It is not intended for human use; it is not a drug, dietary supplement, or cosmetic product. Intended only for qualified researchers.

What is GHRP-6? Scientific Description

GHRP-6 (Growth Hormone-Releasing Peptide-6) is a synthetic hexapeptide belonging to the group of GH secretagogues—compounds studied for their ability to stimulate the secretion of growth hormone (GH) from the pituitary gland. The abbreviation “6” refers to the six amino acid residues that make up its structure: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂.
GHRP-6 was one of the first synthetic GH secretagogues developed as part of research on the ghrelin axis and is among the most extensively preclinically studied peptide compounds in this category. Its research profile is characterized by a potent GH-releasing effect combined with significant activation of the ghrelin receptor, which is relevant to research on metabolism and appetite.

Chemical Structure and Properties

Parameter	Value
Sequence	His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
Class	Synthetic hexapeptide, GH secretagogue
CAS Number	87616-84-0
Molecular weight	873.0 Da
Form (jacked.sk)	5 mg freeze-dried powder
Purity	≥98% (HPLC-verified)
Storage	−20 °C; protect from light and moisture

Mechanism of action – ghrelin receptor GHS-R1a

GH secretion and the pituitary axis

GHRP-6 acts as an agonist of the GHS-R1a receptor (Growth Hormone Secretagogue Receptor 1a)—a receptor identical to the receptor for endogenous ghrelin. Binding to GHS-R1a in somatotropic cells of the anterior pituitary lobe stimulates the pulsatile release of growth hormone. Preclinical studies consistently document the potent GH-secreting effect of GHRP-6, comparable to that of GHRP-2 (Bowers et al., Endocrinology, 1984).

The Ghrelin Effect and Appetite Research

Unlike the more selective Ipamorelin, GHRP-6 exhibits a pronounced ghrelin effect —the activation of ghrelin signaling pathways in the hypothalamus. Ghrelin is an endogenous “hunger hormone” that regulates energy balance. Preclinical studies in animal models have observed a significant increase in food intake following administration of GHRP-6, making this peptide a subject of research in the field of cachexia and metabolic disorders associated with weight loss (Wren et al., Endocrinology, 2000).

Areas of Scientific Research on GHRP-6

Research on Growth Hormone

Preclinical and early clinical studies document the strong GH-secreting activity of GHRP-6. The research focused on the pulsatile pattern of GH secretion, the synergistic effect with GHRH (growth hormone-releasing hormone), and the subsequent increase in IGF-1 (insulin-like growth factor 1) in the liver. GHRP-6 has been used in diagnostic protocols to test pituitary GH reserve.

Research on Cachexia and Appetite

The activation of the ghrelin axis by GHRP-6 is the subject of research in the context of cachexia —a severe metabolic syndrome characterized by involuntary loss of muscle mass and appetite in chronic diseases (cancer, heart failure, AIDS). Preclinical models suggest that GHRP-6 has the potential to increase food intake and maintain body weight. These findings form the basis for research interest, although there is currently no clinical approval.

Cortisol and Prolactin – Research Context

Preclinical studies have shown that GHRP-6 (similar to GHRP-2) simultaneously stimulates the secretion of cortisol and prolactin —unlike the selective Ipamorelin, which does not exhibit these secondary secretions. This research difference is relevant in comparative studies of GH secretagogues and influences the selection of a peptide for specific research protocols.

Comparison of GH Peptides – GHRP-6, GHRP-2, and Ipamorelin

Property	GHRP-6	GHRP-2	Ipamorelin
Class	Hexapeptide	Hexapeptide	Pentapeptide
GH secretion (level)	Strong	Strong	Mild to moderate
Ghrelin Effect	Strong (significant appetite stimulation)	Milder	Minimal
Cortisol/Prolactin	↑ Increases	↑ Increases	Does not increase (selective)
Selectivity	Low	Low	High
Research Interests	Cachexia, appetite, GH	GH, metabolism	Selective GH secretion
Contents (jacked.sk)	5 mg	5 mg	5 mg

Technical Specifications

Parameter	Value
Contents	5 mg freeze-dried powder
Purity	≥98% (HPLC)
CAS Number	87616-84-0
Molecular weight	873.0 Da
Appearance	White freeze-dried powder
Storage	−20 °C (long-term), 4 °C (short-term, up to 4 weeks)
Sterility	This product is not sterile—it is not intended for injection or human use
Intended Use	For scientific research purposes only

Frequently Asked Questions About GHRP-6 (FAQ)

What is GHRP-6, and how does it differ from other GH secretagogues?

GHRP-6 is a synthetic hexapeptide and an agonist of the ghrelin receptor GHS-R1a. Unlike the selective Ipamorelin, GHRP-6 exhibits a strong ghrelin effect—more pronounced appetite stimulation and activation of the ghrelin axis. Compared to GHRP-2, GHRP-6 has comparable GH-secretory potency but a more pronounced effect on ghrelin. The selectivity of GHRP-6 is low—it also stimulates the secretion of cortisol and prolactin.

Why is research on GHRP-6 relevant to the field of cachexia?

Cachexia is a complex metabolic syndrome associated with a loss of appetite, muscle mass, and body weight in severe chronic diseases. Preclinical studies in animal models suggest that the ghrelin-like activity of GHRP-6 may increase food intake and modulate energy balance. These results serve as a basis for research into potential therapeutic approaches to cachexia, despite the lack of existing clinical approval for GHRP-6.

What is the difference between GHRP-6 and Ipamorelin from a research perspective?

Ipamorelin is a selective GH secretagogue—it stimulates GH secretion without significantly increasing cortisol, prolactin, or ghrelin. GHRP-6 is less selective: in addition to GH, it also stimulates cortisol, prolactin, and the ghrelin axis. For research where selective GH secretion without hormonal side effects is important, preclinical protocols prefer Ipamorelin. For research on the ghrelin axis and appetite, GHRP-6 is the more suitable choice.

Is GHRP-6 registered as a drug in the European Union?

No. GHRP-6 is not approved as a drug in the European Union or in the U.S. (FDA). Historically, it has been used in diagnostic testing of pituitary GH reserve, but it is not available as a clinically approved drug. On jacked.sk, it is sold exclusively for scientific research purposes.

How should GHRP-6 5 mg be stored?

We recommend storing the 5 mg freeze-dried GHRP-6 powder at −20 °C, protected from light and moisture. Short-term storage at 4 °C is possible for up to 4 weeks. Reconstitution can be performed in bacteriostatic water according to the research protocol—see the Dosage Calculator section on jacked.sk for details.

What is the purity of GHRP-6 5 mg on jacked.sk?

GHRP-6 5 mg has a purity of ≥98%, verified by HPLC. CAS number 87616-84-0 confirms the compound’s identity. A Certificate of Analysis (COA) is available upon request in the /certificates-of-analysis/ section.

⚠️ Warning – Intended exclusively for research purposes

All products sold on jacked.sk are intended EXCLUSIVELY for scientific research purposes. They are not intended for use as a medicine, drug, dietary supplement, or cosmetic product, nor for human or veterinary use. The results cited in the descriptions are based on preclinical studies (in vitro, animal models) and cannot be automatically extrapolated to human use. Sale restricted to individuals over the age of 18. By purchasing this product, the customer confirms that they are a professional researcher and will use the product solely in accordance with applicable laws.