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5-amino-1MQ NNMT inhibítor pre výskum jacked.sk

5-Amino-1MQ 50 mg

Original price was: 74,99 €.Current price is: 49,99 €. with VAT

5-amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase)—a metabolic regulator expressed primarily in adipose tissue. By inhibiting NNMT, it redirects nicotinamide back into the NAD⁺ salvage pathway, thereby increasing intracellular NAD⁺ levels and modulating SAM-dependent methylation in adipocytes. In a key preclinical study (Neelakantan et al., 2018), it reduced body weight and white adipose tissue mass in obese mice without altering food intake.

Purity ≥ 98% – Each batch verified by HPLC; COA available upon request
Freeze-dried powder, store at −20 °C
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7+	44,99 €	10%
4+	47,49 €	5%

Category: Research on Weight Loss and Metabolism

All products are sold exclusively for the purpose of scientific research and development.
The chemical substances may not be used as a medicine, drug, active substance, medical device, cosmetic product, substance for the manufacture of a cosmetic product, or as a substance for human consumption, i.e. as a food or nutritional supplement, or in any other similar way on humans or animals.

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Description

5-Amino-1MQ 50 mg — Selective NNMT Inhibitor for Research in Metabolism and Adipocyte Biology

⚠️ Warning: This product is intended exclusively for scientific research and laboratory use. It is not intended for human or veterinary use, nor for the diagnosis, treatment, or prevention of any disease. Sale restricted to individuals over the age of 18.
5-amino-1MQ (5-amino-1-methylquinolinium) represents a new type of research tool in the field of metabolic biology. Unlike peptide compounds that specifically activate receptors (GLP-1, GIP), 5-amino-1MQ acts intracellularly as an enzyme inhibitor —it blocks NNMT (nicotinamide N-methyltransferase), an enzyme identified as a key regulator of fat metabolism, energy expenditure, and cell biology.
It was first characterized by a research group at the University of Texas Health Science Center and represents pharmacological confirmation of the genetic findings of the Kraus group, which demonstrated that NNMT knockout in mice leads to resistance to diet-induced obesity.

Chemical Identity

Parameter	Value
Full name	5-amino-1-methylquinolinium
Abbreviation	5-amino-1MQ
Compound Type	Small-molecule NNMT inhibitor (non-peptide)
IC₅₀ against NNMT	1.2 μM
Form	Freeze-dried powder
Purity	≥98% (HPLC)

What is NNMT, and why is it a research goal?

NNMT (nicotinamide N-methyltransferase) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, resulting in the formation of 1-methylnicotinamide (1-MNA). This reaction has implications on two levels:

It diverts nicotinamide from the NAD+ salvage pathway → reducing the intracellular capacity to regenerate NAD+
Depletes SAM for methylation → SAM is a universal donor of methyl groups for epigenetic modifications (DNA and histone methylation)

NNMT is overexpressed in the adipose tissue of obese individuals and in cases of insulin resistance, making it the subject of intensive research as a therapeutic target for metabolic diseases.

Mechanism of Action of 5-Amino-1MQ

The NAD+ Axis

By blocking NNMT, nicotinamide is not diverted to the formation of 1-MNA but remains available for the NAD+ salvage pathway (NAMPT):

↑ intracellular NAD+
↑ sirtuin activity (SIRT1/SIRT3)
↑ mitochondrial biogenesis

SAM / Epigenetics

Without nicotinamide methylation, SAM is not degraded and remains available for epigenetic methylation:

↑ SAM available for DNA and histone methylation
Modulation of Gene Expression in Adipocytes

In vitro and in vivo (animal models) results:

Increase in intracellular NAD+ levels in adipocytes
Activation of thermogenesis in white adipose tissue (browning effect)
Reduction in adipogenesis and adipocyte size
Improved insulin sensitivity (GLUT4 expression)
Preserving Muscle Mass While Reducing Body Fat

Key Preclinical Studies

Neelakantan et al. (2018) — Biochemical Pharmacology

Selective, membrane-permeable, small-molecule NNMT inhibitors reverse obesity induced by a high-fat diet in mice.

Model: diet-induced obese mice (C57BL/6), 11 days, 20 mg/kg 3 times daily s.c.
A significant reduction in body weight (p < 0.05) and white adipose tissue mass (p < 0.01) without any change in food intake
A reduction in plasma cholesterol (p < 0.05) and adipocyte size (p < 0.0001)
Selectivity: IC₅₀ = 1.2 μM against NNMT

Sampson et al. (2021) — Scientific Reports

Combination of an NNMT inhibitor with dietary intervention in obese mice. The combination of 5-amino-1MQ and a low-calorie diet significantly reduced body weight, fat mass, liver fat content, and hepatic steatosis beyond the effects of either intervention alone.

Dimet-Wiley et al. (2024) — Scientific Reports

NNMT inhibition mimics and enhances the effects of exercise on muscle function in aged mice. The combination of an NNMT inhibitor and exercise resulted in a 60% improvement in grip strength compared with sedentary controls; 5-amino-1MQ alone produced a 40% improvement—suggesting a mechanism distinct from exercise.
⚠️ Important: None of these studies were conducted in humans. All results come from preclinical animal models. The transferability to human biology has not been confirmed.

5-Amino-1MQ vs. GLP-1 Agonists — A Research Perspective

Parameter	5-amino-1MQ	GLP-1 agonists
Mechanism	NNMT inhibition (intracellular)	Receptor agonism (extracellular)
Target organ	Adipose tissue, muscles	Pancreas, brain, GI tract
Effect on appetite	No (in vitro data)	Yes (central effect)
Maintenance of Muscle Mass	Yes (animal models)	Partially
Clinical experience	None (preclinical only)	Extensive Phase 3 / Approved
Effect on NAD+	Yes (via the salvage pathway)	No

5-amino-1MQ is a tool of research interest for an alternative approach to metabolic biology—the combination of NNMT inhibition with incretin mimetics is an active research hypothesis.

Technical Specifications

Parameter	Value
Contents per package	50 mg
Form	Freeze-dried powder (vial)
Purity	≥98% (HPLC-verified)
Recommended solvent	DMSO (for stock solution), then dilute with PBS
Storage – freeze-dried	−20 °C, protect from light
Storage – after reconstitution	−20 °C in aliquots; avoid repeated thawing
Intended Use	Exclusively preclinical/laboratory research
Age Restriction	18+

Frequently Asked Questions About 5-Amino-1MQ (FAQ)

What is 5-amino-1MQ, and what does it do?

5-amino-1MQ is a small-molecule inhibitor of the NNMT enzyme. By blocking NNMT, it redirects nicotinamide to the NAD+ salvage pathway (↑ NAD+) and preserves SAM for methylation in adipocytes, leading to the modulation of fat metabolism in preclinical models.

Is 5-amino-1MQ a peptide?

No. Unlike BPC-157, TB-500, or SS-31, 5-amino-1MQ is a small-molecule organic inhibitor (a quinoline salt)—not a peptide. Jacked.sk classifies it as a research compound.

Are there any clinical studies in humans involving 5-amino-1MQ?

As of July 2026, no human clinical studies had been published. All available data come from preclinical animal models. The applicability of these results to humans has not been confirmed.

How does 5-amino-1MQ differ from GLP-1 agonists?

GLP-1 agonists reduce appetite via the central nervous system and are clinically approved. 5-amino-1MQ acts through a different mechanism (NNMT inhibition, intracellular) without affecting appetite in preclinical models—a distinction of research interest.

How should 5-amino-1MQ be stored?

Freeze-dried powder at −20 °C, protected from light. We recommend using DMSO for the stock solution, followed by dilution into an aqueous buffer (PBS). Store reconstituted solutions in aliquots at −20 °C.

⚠️ Final Disclaimer

5-amino-1MQ, available at jacked.sk, is a research compound intended exclusively for laboratory and preclinical studies. It is not approved by any regulatory authority (FDA, EMA, ŠÚKL) for human use. It is not a drug, nor is it a dietary supplement. The seller is not liable for any use that violates these terms and conditions.