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Thymosin Alpha 1 10 mg

Original price was: 64,99 €.Current price is: 29,99 €. with VAT

Thymosin Alpha-1 is a 28-amino acid polypeptide naturally produced by the thymus gland and one of the most thoroughly studied immunomodulatory peptides since the 1970s. Research focuses on T-cell differentiation, dendritic cell activation, and the regulation of pro-inflammatory cytokines.

Purity ≥ 98% – Each batch verified by HPLC; COA available upon request
10 mg of lyophilized powder, store at −20 °C
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4+	28,49 €	5%

Category: Research on Tissue Regeneration and Healing

All products are sold exclusively for the purpose of scientific research and development.
The chemical substances may not be used as a medicine, drug, active substance, medical device, cosmetic product, substance for the manufacture of a cosmetic product, or as a substance for human consumption, i.e. as a food or nutritional supplement, or in any other similar way on humans or animals.

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Description

Thymosin Alpha-1 10 mg – Immunomodulatory Peptide for Immunity Research

⚠️ Legal Notice: Thymosin Alpha-1 is intended exclusively for scientific and research purposes. It is not intended for human use as a medication, dietary supplement, or cosmetic product. Sale restricted to individuals over the age of 18.

What is Thymosin Alpha-1?

Thymosin Alpha-1 (abbreviated as Tα1 or TA1) is a 28-amino acid polypeptide that is naturally produced and secreted by the thymus gland. It is a biologically active fragment of a larger precursor protein—prothymosin alpha. The natural sequence of the peptide begins with an acetylated serine-alanine-alanine-valine core:
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Thymosin Alpha-1 has been one of the most thoroughly studied immunomodulatory peptides since the 1970s. Research into its biological activity was initiated in the United States, where Dr. Allan Goldstein’s team identified and isolated the first thymosin fractions. Today, Tα1 is the subject of international scientific interest, particularly in the fields of immunology, oncology, and infectious diseases.
Important: Thymosin Alpha-1 is not approved as a drug for general use in the European Union. All available preclinical and clinical data serve as a basis for further scientific research and are accessible in PubMed databases.

Mechanism of Action – How Tα1 Works in Research

Modulation of T-cell Differentiation and Proliferation

Research has identified Thymosin Alpha-1 as a regulator of T-lymphocyte differentiation and maturation in the thymus. In preclinical studies, Tα1 has been shown to influence the conversion of immature thymocytes into functional T cells (CD4+ and CD8+). This mechanism is the subject of research in the context of conditions associated with thymus dysfunction or immunosuppression.

Activation of dendritic cells

Dendritic cells are key antigen-presenting cells of the immune system—they bridge innate and adaptive immunity. Research has shown that Tα1 can stimulate the maturation and activation of dendritic cells, thereby potentially enhancing antigen presentation to T lymphocytes. This mechanism is being studied in the field of adjuvants in immunological research.

Regulation of pro-inflammatory cytokines

Preclinical studies document the modulatory effect of Tα1 on the production of key cytokines involved in the immune response, including IL-2 (interleukin-2) and IFN-γ (interferon-gamma). Both cytokines play a central role in cellular immunity and antiviral defense. Research is investigating how Tα1 regulates the balance between inflammatory and anti-inflammatory responses.
Sources: Goldstein AL. et al., Thymosin alpha 1 – Annals of the New York Academy of Sciences (2007); Tuthill C. et al., Expert Opinion on Biological Therapy (2006)

Research Areas: Thymosin Alpha-1

Immunodeficiency and Tumor Immunology

Thymosin Alpha-1 has been studied as a potential immunorestorative agent in conditions characterized by impaired T-cell function. In the field of tumor immunology, Tα1 has been tested as an adjuvant in combination with other modalities—the hypothesis being that restoring immune competence may enhance the body’s antitumor mechanisms.

Sepsis – Preclinical Models

Several preclinical studies have investigated Tα1 in sepsis models (CLP models in rodents). The results suggest a potential for modulating the immune response in the context of systemic inflammatory syndrome. However, these data come exclusively from animal models, and their translation into clinical practice requires further research.

Research in the Context of Viral Infections (2020–2022)

Between 2020 and 2022, several observational studies and pilot clinical trials were published that focused on the potential immunomodulatory role of Tα1 in severe viral infections. These studies primarily examined the modulation of the inflammatory response and the restoration of T-cell function. The results are preliminary and do not imply any clinical recommendations.

Clinical and Regulatory Context: Zadaxin®

Thymosin Alpha-1 was commercially developed under the name Zadaxin® (thymalfasin) by SciClone Pharmaceuticals. Zadaxin® is approved in more than 35 countries (primarily in Asia, Latin America, and the Middle East) as a treatment for chronic hepatitis B, hepatitis C, and as an adjuvant therapy for certain cancers.
Important Notice: Zadaxin® is not approved by the European Medicines Agency (EMA) or the U.S. FDA for these indications. Thymosin Alpha-1 sold on jacked.sk is not the same as Zadaxin®—it is a research compound intended exclusively for laboratory and scientific purposes, not for human use.

Technical Specifications

Parameter	Value
Chemical Name	Thymosin Alpha-1 (Thymalfasin, Tα1)
Sequence length	28 amino acids
Molecular weight	3,108.3 Da
CAS Number	62304-98-7
Form	Lyophilized (freeze-dried) white powder
Contents per package	10 mg
Purity	≥ 98% (HPLC-verified)
Recommended storage conditions	−20 °C, protected from light and moisture
Intended Use	For scientific research purposes only

Frequently Asked Questions About Thymosin Alpha-1

What is Thymosin Alpha-1, and where does it come from?

Thymosin Alpha-1 (Tα1) is a 28-amino acid polypeptide naturally produced by the thymus gland. It was isolated and characterized in the 1970s by a team led by Dr. Allan Goldstein (George Washington University). It is the subject of scientific research in the fields of immunology, oncology, and infectious diseases.

What is the relationship between Thymosin Alpha-1 and Zadaxin®?

Zadaxin® (thymalfasin) is a commercial pharmaceutical product containing synthetic Thymosin Alpha-1. It is approved in some Asian and Latin American countries. Thymosin Alpha-1 on jacked.sk is a research compound—not a drug and not Zadaxin®. It is not intended for human use.

In which areas of research is Tα1 being studied?

Research on Tα1 focuses on the modulation of T-cell differentiation, the activation of dendritic cells, the regulation of the cytokine response (IL-2, IFN-γ), immunodeficiency-related conditions, and tumor immunology. All available data come from preclinical and limited clinical research.

How should Thymosin Alpha-1 be stored?

Store unopened packages at −20 °C, protected from light and moisture. Avoid repeated thawing and freezing. After reconstitution, store at 4 °C and use promptly in accordance with the research protocol.

Is Thymosin Alpha-1 approved as a drug in the EU?

No. Zadaxin® (thymalfasin) is not approved by the European Medicines Agency (EMA) for any indication. Thymosin Alpha-1 sold on jacked.sk is not a medicinal product—it is a research compound intended exclusively for scientific and laboratory purposes.

What is the purity of the product?

Thymosin Alpha-1 from jacked.sk has a purity of ≥98%, verified by HPLC. A Certificate of Analysis (COA) is available upon request.

⚠️ Warning – Intended exclusively for research purposes

All products sold on jacked.sk are intended EXCLUSIVELY for scientific research purposes. They are not intended for use as a medicine, drug, dietary supplement, or cosmetic product, nor for human or veterinary use. The results cited in the descriptions are based on preclinical studies (in vitro, animal models) and cannot be automatically extrapolated to human use. Sale restricted to individuals over the age of 18. By purchasing this product, the customer confirms that they are a professional researcher and will use the product solely in accordance with applicable laws.