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MELANOTAN-2 10 mg

Original price was: 39,99 €.Current price is: 32,99 €. with VAT

Melanotan-2 is a cyclic synthetic heptapeptide and an analog of the hormone α-MSH, developed at the University of Arizona as a tool for studying melanocortin signaling. It is studied through two receptors: MC1R in the context of melanogenesis and photoprotection, and MC4R in the context of food intake and sexual function.

Purity ≥ 98% – Each batch verified by HPLC; COA available upon request
10 mg of lyophilized powder, stable for 24 months at −20 °C
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All products are sold exclusively for the purpose of scientific research and development.
The chemical substances may not be used as a medicine, drug, active substance, medical device, cosmetic product, substance for the manufacture of a cosmetic product, or as a substance for human consumption, i.e. as a food or nutritional supplement, or in any other similar way on humans or animals.

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Description

Melanotan-2 10 mg – Synthetic α-MSH Analog for Pigmentation Research

⚠️ Warning: Melanotan-2 is intended exclusively for scientific and research purposes. It is not intended for human use as a medication, dietary supplement, or cosmetic product. Melanotan-2 is not approved as a drug in the European Union or by the FDA. Sale exclusively to persons over the age of 18.

What is Melanotan-2?

Melanotan-2 (MT-2) is a cyclic synthetic heptapeptide —an analog of the natural hormone α-MSH (alpha-melanocyte-stimulating hormone). α-MSH is an endogenous hormone produced by the pituitary gland that plays a key role in regulating skin pigmentation, energy metabolism, and sexual function through the activation of melanocortin receptors.
Melanotan-2 was originally developed at the University of Arizona in the 1980s and 1990s as a research tool for studying melanocortin signaling. The development was motivated by research into the potential protection of the skin against UV radiation through the stimulation of melanogenesis.

Amino Acid Sequence and Structure

Melanotan-2 amino acid sequence:Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
The cyclic structure of the peptide (a lactam bond between Asp and Lys) increases its resistance to enzymatic degradation compared to linear α-MSH, which prolongs its half-life. The substitutions Met→Nle (norleucine) and Phe→D-Phe increase the affinity for melanocortin receptors.

Melanotan-2 is not an approved drug – research context

Melanotan-2 has never been approved by a regulatory agency (the EMA, FDA, or any other) as a drug. The European Medicines Agency (EMA) has issued several warnings regarding its illegal sale outside of a research context. All Melanotan-2 products on jacked.sk are intended exclusively for scientifically trained researchers working under regulated laboratory conditions.

The Melanocortin System—The Basis for MT-2 Research

Melanotan-2 acts as an agonist of melanocortin receptors (MC receptors). There are five types of MC receptors (MC1R–MC5R), and MT-2 has the highest affinity for MC1R and MC4R:

MC1R – Research on Pigmentation and Melanogenesis

MC1R (Melanocortin 1 Receptor) is expressed primarily on melanocytes —the pigment-producing cells of the skin. Its activation leads to: – Stimulation of melanogenesis—the synthesis of melanin pigment (preferentially eumelanin, black/brown) – Activation of the enzyme tyrosinase (a key step in melanin biosynthesis)- In vitro studies suggest a potential photoprotective role of eumelanin against UV-induced DNA damage
Research on MC1R activation is relevant to dermatology, skin oncology, and photobiology.

MC4R – Research on Sexual Function and the Regulation of Food Intake

MC4R (Melanocortin 4 Receptor) is expressed primarily in the central nervous system (hypothalamus). It is involved in: – Regulation of sexual arousal and erectile function (research in animal models and clinical studies) – Regulation of food intake and energy expenditure (MC4R mutations are associated with monogenic obesity in human populations)—Research on MC4R agonists is the subject of intense interest in the fields of sexual medicine and metabolic research

Areas of Preclinical Research on Melanotan-2

Research on Melanogenesis and Photoprotection (in vitro)

Studies on cultured melanocytes and mouse models show that MT-2 administration leads to a statistically significant increase in eumelanin synthesis. In some experiments using a mouse model (C57BL/6 mice), darkening of the fur was observed following systemic administration of MT-2, which serves as an in vivo marker of MC1R activation.
The research hypothesis regarding the photoprotective effect of increased eumelanin (potential protection against UV-induced carcinogenesis) is the subject of a long-term study; however, clinical confirmation of this effect is not available.

Research on Sexual Function

Preclinical studies in animal models have documented the pro-erectile effects of Melanotan-2 through MC4R agonism in the CNS. These results led to the development of a more selective MC4R agonist— PT-141 (Bremelanotide) —which was later tested in clinical trials.
Bremelanotide (derived from MT-2) received FDA approval in 2019 under the brand name Vyleesi® for the treatment of hypoactive sexual desire disorder in premenopausal women. This approval applies exclusively to Bremelanotide/PT-141, not to Melanotan-2.

Research on Weight Control

MC4R activation in the hypothalamus (arcuate nucleus) modulates satiety and energy expenditure signaling. In preclinical studies, chronic administration of MT-2 was associated with a reduction in food intake and body weight. This mechanism is the subject of research in the context of obesity and metabolic syndrome.

Melanotan-2 vs. PT-141 (Bremelanotide)

Property	Melanotan-2 (MT-2)	PT-141 (Bremelanotide)
Peptide Type	Cyclic heptapeptide	Cyclic heptapeptide
Receptor Profile	MC1R + MC4R (+ MC3R)	Primarily MC4R
Effect on Pigmentation	YES (MC1R)	Minimal
Research on Sexual Function	YES (MC4R)	YES – primary interest
Regulatory Status	Not approved (EU/FDA)	FDA-approved (Vyleesi®, 2019)
MW	1,024 Da	1,025 Da

PT-141 is a metabolic derivative of Melanotan-2 with higher selectivity for MC4R, while MT-2 has a broader melanocortin profile with significant activity at MC1R.

Technical Specifications

Parameter	Value
Chemical Name	Melanotan-2 (MT-2)
IUPAC / Sequence	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Molecular weight	1,024.2 Da
CAS Number	121062-08-6
Contents per package	10 mg
Purity	≥ 98% (HPLC-verified)
Product Form	Freeze-dried white powder
Recommended storage conditions	−20 °C, protected from light and moisture
Stability (lyophilisate)	Up to 24 months at −20 °C
Stability (reconstituted)	Up to 28 days at 4 °C
Regulatory Status	Unapproved drug (EU/FDA); for research purposes only
Intended Use	For scientific research purposes only

Frequently Asked Questions About Melanotan-2

What is Melanotan-2, and how was it discovered?

Melanotan-2 is a synthetic cyclic heptapeptide, an analog of the natural hormone α-MSH. It was developed at the University of Arizona in the 1980s as part of research into melanogenesis and photoprotection. A research team led by Dr. Melvil Hadley synthesized it as a potential anticancer agent—by stimulating melanogenesis prior to UV exposure. However, it was never approved as a drug.

What is the difference between Melanotan-1 and Melanotan-2?

Melanotan-1 (afamelanotide) is a linear analog of α-MSH with primary activity at MC1R and minimal effect on MC4R. It is approved in the EU under the name Scenesse® for erythropoietic protoporphyria (a rare genetic disorder characterized by sensitivity to light). Melanotan-2 is a cyclic peptide with activity at both MC1R and MC4R. Both peptides are distinct molecules with different regulatory statuses.

Why isn't Melanotan-2 approved as a drug?

Clinical trials of Melanotan-2 were conducted, but development of the drug was halted. The reasons include side effects observed in clinical trials (nausea, facial flushing) and the fact that research has shifted toward more selective analogs—Melanotan-1 (for pigmentation indications) and PT-141/Bremelanotide (for sexual dysfunction). Melanotan-2 remains a research compound without clinical approval.

How should Melanotan-2 10 mg be stored?

Store the lyophilized powder at −20 °C in its original packaging, protected from light and moisture. After reconstitution with bacteriostatic water, store at 4 °C (for up to 28 days). Before use in research, allow the vial to come to room temperature and gently swirl it—do not shake the peptide.

What is the relationship between Melanotan-2 and PT-141?

PT-141 (Bremelanotide) was originally developed as a metabolite of Melanotan-2. Clinical research has shown that activity at the MC4R (relevant to research on sexual function) can be achieved without significant MC1R activity. PT-141 is a more selective MC4R agonist with minimal effect on pigmentation. The FDA approved Bremelanotide in 2019 as Vyleesi® for hypoactive sexual desire disorder in women—this approval does not apply to Melanotan-2.

Is Melanotan-2 legal in Slovakia?

Melanotan-2 is not listed in the EU as a controlled psychotropic substance or narcotic. Furthermore, it is not approved as a medication, and its sale as a medication is prohibited. Purchases for scientific and research purposes within a regulated laboratory setting are in compliance with applicable legislation. Jacked.sk sells Melanotan-2 exclusively for scientific research purposes, not for human use.

⚠️ Warning – Intended exclusively for research purposes

All products sold on jacked.sk are intended EXCLUSIVELY for scientific research purposes. They are not intended for use as a medicine, drug, dietary supplement, or cosmetic product, nor for human or veterinary use. The results cited in the descriptions are based on preclinical studies (in vitro, animal models) and cannot be automatically extrapolated to human use. Sale restricted to individuals over the age of 18. By purchasing this product, the customer confirms that they are a professional researcher and will use the product solely in accordance with applicable laws.