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Semax 20 mg

Original price was: 49,99 €.Current price is: 24,99 €. with VAT

Semax is a synthetic heptapeptide—an analog of the ACTH(4-7) fragment with a Pro-Gly-Pro extension, which gives it significantly greater metabolic stability. Research focuses on BDNF expression, neuroprotection in ischemic brain injury, and cognitive function.

Purity ≥ 98% – Each batch verified by HPLC; COA available upon request
20 mg of lyophilized powder, store at −20 °C
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Only 10 left in stock

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Quantity	Price	% Discount
7+	22,49 €	10%
4+	23,74 €	5%

Category: Research on Cognitive Functions

All products are sold exclusively for the purpose of scientific research and development.
The chemical substances may not be used as a medicine, drug, active substance, medical device, cosmetic product, substance for the manufacture of a cosmetic product, or as a substance for human consumption, i.e. as a food or nutritional supplement, or in any other similar way on humans or animals.

All customers MUST be at least 18 years of age to purchase our products.

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Description

H1: Semax 20 mg – A Neuropeptide for Research on Cognitive Functions and BDNF

⚠️ Warning: Semax sold on jacked.sk is intended exclusively for scientific research purposes (research use only). It is not intended for human use; it is not a drug, dietary supplement, or cosmetic product. Intended only for qualified researchers.

What is Semax? Scientific description and origin

Semax is a synthetic heptapeptide with the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro. It is an analog of the adrenocorticotropic hormone (ACTH) fragment (4-7) with a Pro-Gly-Pro extension, which, according to research data, provides it with increased metabolic stability compared to the original fragment.
Semax was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences (IMGen RAN) in Moscow during the 1990s. In the Russian Federation, Semax is registered as a medicinal product—however, this registration is not valid in European Union countries or in the United States (FDA). In the context of international research, Semax is classified among the nootropic neuropeptides being studied for their potential neuroprotective and cognitive properties.

Chemical Structure and Properties

Parameter	Value
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
Class	Synthetic heptapeptide, an analog of ACTH(4-7)
Form (jacked.sk)	20 mg freeze-dried powder
Purity	≥98% (HPLC-verified)
Storage	−20 °C; protect from light and moisture
Administration in Research	Intranasal Administration (Research Protocols)

The Pro-Gly-Pro extension increases the peptide’s resistance to enzymatic degradation, which is relevant from a research perspective for bioavailability studies. The intranasal route of administration used in preclinical protocols is the subject of research, particularly due to its potential to cross the blood-brain barrier (BBB).

Mechanism of Action – How Semax Works in Research

Modulation of ACTH Receptors

Semax exhibits affinity for adrenocorticotropic hormone receptors, and preclinical studies suggest that its mechanism of action differs from that of the full ACTH molecule—it does not involve the glucocorticoid axis. Research is primarily focused on its activity in the central nervous system.

Research on BDNF Expression

One of the most actively studied areas is the effect of Semax on the expression of BDNF (Brain-Derived Neurotrophic Factor) —a neurotrophic factor essential for the survival, growth, and differentiation of neurons, as well as for synaptic plasticity. Preclinical studies in animal models have observed increased BDNF levels following Semax administration (Dolotov et al., 2006, Journal of Molecular Neuroscience). Low levels of BDNF are associated in the research literature with conditions such as depression, Alzheimer’s disease, and cognitive decline—making BDNF modulation an active area of neuroscience research.

Semax’s Areas of Scientific Research

Neuroprotection and Ischemic Brain Injury

Preclinical studies in animal models suggest that Semax has neuroprotective potential in ischemic brain injury. The research observed a reduction in the extent of the infarct area and modulation of inflammatory markers following experimental cerebral ischemia (Gusev et al., 2018, Molecular Genetics, Microbiology and Virology). These results pertain exclusively to animal models.

Research on Memory and Learning

Studies in rodent models have observed the potential effect of Semax on learning and memory consolidation processes. Researchers noted improved performance in spatial navigation tests (Maisov et al.). The mechanism is associated with the modulation of the dopaminergic and serotonergic systems in the hippocampus.

Research on ADHD-like Conditions

Research in the field of neuroscience has examined Semax in the context of ADHD-like phenotypes in animal models. Preclinical data suggest modulation of attention and impulsive behavior, which represents a fundamental area of research interest without clinical application in the EU.

Technical Specifications

Parameter	Value
Contents	20 mg freeze-dried powder
Purity	≥98% (HPLC)
Appearance	White to grayish-white lyophilized powder
Storage	−20 °C (long-term), 4 °C (short-term, up to 4 weeks)
Sterility	This product is not sterile—it is not intended for injection or human use
Intended Use	For scientific research purposes only

Frequently Asked Questions About Semax (FAQ)

What is Semax, and how was it developed?

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences in Moscow. It is an analog of the ACTH(4-7) fragment with a Pro-Gly-Pro extension that increases its metabolic stability. It is registered as a medicinal product in the Russian Federation; however, this approval is not valid in the EU or the U.S. It is available on jacked.sk exclusively for scientific research purposes.

What is BDNF, and why is it relevant to Semax research?

BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophic factor essential for neuronal survival, synaptic plasticity, and learning processes. Preclinical studies in animal models have observed an increase in BDNF expression following Semax administration, which has sparked research interest in the field of neurology. Low levels of BDNF are associated in the scientific literature with neurological disorders such as depression and Alzheimer’s disease—therefore, BDNF modulation is an actively researched area.

What is the recommended route of administration in research protocols?

Published research protocols list intranasal administration as the primary route of administration. Research suggests that this route may allow the peptide to cross the blood-brain barrier (BBB). All information regarding administration is provided solely for scientific and informational purposes—it is not a recommendation for use in humans.

Is Semax registered as a drug in the European Union?

No. Semax is registered as a medication exclusively in the Russian Federation. In the European Union, the U.S., or other Western countries, it does not have the status of a drug or dietary supplement. The products available on jacked.sk are intended solely for scientific research purposes by qualified professionals.

How should Semax 20 mg be stored to ensure the stability of the peptide?

It is recommended to store Semax 20 mg lyophilized powder at −20 °C, protected from light and moisture. For short-term storage (up to 4 weeks), a temperature of 4 °C is sufficient. Stability is reduced after reconstitution in bacteriostatic water. A detailed reconstitution protocol can be found in the Dosage Calculator section.

What is the purity of Semax on jacked.sk, and how is it verified?

Semax 20 mg, available at jacked.sk, has a purity of ≥98%, verified by HPLC (high-performance liquid chromatography). HPLC analysis is the standard method for verifying the identity, purity, and concentration of synthetic peptides in laboratory research. A Certificate of Analysis (COA) is available upon request.

⚠️ Warning – Intended exclusively for research purposes

All products sold on jacked.sk are intended EXCLUSIVELY for scientific research purposes. They are not intended for use as a medicine, drug, dietary supplement, or cosmetic product, nor for human or veterinary use. The results cited in the descriptions are based on preclinical studies (in vitro, animal models) and cannot be automatically extrapolated to human use. Sale restricted to individuals over the age of 18. By purchasing this product, the customer confirms that they are a professional researcher and will use the product solely in accordance with applicable laws.