{"id":9427,"date":"2026-08-13T15:24:56","date_gmt":"2026-08-13T13:24:56","guid":{"rendered":"https:\/\/dev.jacked.sk\/uncategorized\/nad-500-mg\/"},"modified":"2026-08-24T15:43:01","modified_gmt":"2026-08-24T13:43:01","slug":"nad-500-mg","status":"publish","type":"product","link":"https:\/\/dev.jacked.sk\/en\/research-on-longevity-and-the-slowing-of-aging\/nad-500-mg\/","title":{"rendered":"NAD+ 500 mg"},"content":{"rendered":"<div class=\"row read-more\"  id=\"row-188331656\">\n\n\t<div id=\"col-51923181\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h1>NAD+ 500 mg \u2014 An Essential Coenzyme for Research on Cellular Energy, Aging, and DNA Repair<\/h1>\n<p>\u26a0\ufe0f <strong>Warning:<\/strong> This product is intended exclusively for scientific research and laboratory use. It is not intended for human or veterinary consumption, nor for the diagnosis, treatment, or prevention of any diseases. Sale restricted to individuals over the age of 18.<br \/>\n<strong>NAD+<\/strong> (nicotinamide adenine dinucleotide) is a fundamental biological coenzyme without which cellular respiration is impossible in any living organism. It is of particular interest to researchers because its levels decline <strong>by up to 50%<\/strong> with age <strong>by middle age<\/strong>, which correlates with impaired mitochondrial function, reduced sirtuin activity, and the accumulation of DNA damage\u2014key hallmarks of biological aging.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-327024860\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Chemical Identity<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Parameter<\/strong><\/td>\n<td><strong>Value<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Full name<\/td>\n<td>Nicotinamide adenine dinucleotide (oxidized form)<\/td>\n<\/tr>\n<tr>\n<td>Abbreviation<\/td>\n<td>NAD\u207a<\/td>\n<\/tr>\n<tr>\n<td>CAS Number<\/td>\n<td>53-84-9<\/td>\n<\/tr>\n<tr>\n<td>Molecular weight<\/td>\n<td>663.43 Da<\/td>\n<\/tr>\n<tr>\n<td>Molecular formula<\/td>\n<td>C\u2082\u2081H\u2082\u2087N\u2087O\u2081\u2084P\u2082<\/td>\n<\/tr>\n<tr>\n<td>Form<\/td>\n<td>Freeze-dried powder<\/td>\n<\/tr>\n<tr>\n<td>Purity<\/td>\n<td>\u226598% (HPLC)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-394412144\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Biological Functions of NAD+ Relevant to Research<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-266749756\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3>1. Electron carrier in cellular respiration<\/h3>\n<p>NAD+ serves as an electron acceptor in glycolysis, the Krebs cycle, and beta-oxidation of fatty acids. It is reduced to NADH, which subsequently donates electrons to the electron transport chain (Complex I \u2192 III \u2192 IV) for ATP production. Without sufficient NAD+, mitochondrial respiration is limited.  <\/p>\n<h3>2. Substrates for sirtuins (SIRT1\u20137) \u2014 research on aging<\/h3>\n<p>Sirtuins are NAD+-dependent deacetylases that regulate gene expression, stress responses, and metabolic pathways. Without NAD+, sirtuins do not function: <\/p>\n<ul>\n<li><strong>SIRT1<\/strong> \u2014 regulation of inflammatory pathways, mitochondrial biogenesis<\/li>\n<li><strong>SIRT3<\/strong> \u2014 mitochondrial homeostasis, reduction of oxidative stress<\/li>\n<li><strong>SIRT6<\/strong> \u2014 DNA repair, telomere regulation<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-701566346\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3>3. Substrate for PARP enzymes \u2014 DNA repair<\/h3>\n<p>Poly(ADP-ribose) polymerases (PARP1, PARP2) consume NAD+ during the detection and repair of single-strand DNA breaks. In models of DNA damage (UV radiation, oxidative stress), high NAD+ consumption for PARP activity is a key research phenomenon. <\/p>\n<h3>4. Substrates for CD38 and SARM1 \u2014 Inflammation and Neuroscience<\/h3>\n<p>CD38 (cyclic ADP-ribose hydrolase) and SARM1 are enzymes that degrade NAD+ in inflammatory and neurodegenerative processes. Research into their inhibition or modulation requires accessible NAD+ as a research tool.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1641424615\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Research Areas<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Field<\/strong><\/td>\n<td><strong>Related Mechanisms<\/strong><\/td>\n<td><strong>State of Research<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Cell Aging<\/td>\n<td>Sirtuins, mitochondrial biogenesis, telomeres<\/td>\n<td>Preclinical + early human studies<\/td>\n<\/tr>\n<tr>\n<td>Mitochondrial Biology<\/td>\n<td>ETC efficiency, ATP production, NAD\/NADH ratio<\/td>\n<td>Preclinical (in vitro + in vivo)<\/td>\n<\/tr>\n<tr>\n<td>DNA Repair<\/td>\n<td>PARP enzymes, SSB\/DSB repair<\/td>\n<td>Preclinical and in vitro models<\/td>\n<\/tr>\n<tr>\n<td>Neuroprotection<\/td>\n<td>SARM1 inhibition, axonal degeneration<\/td>\n<td>Preclinical<\/td>\n<\/tr>\n<tr>\n<td>Metabolic Health<\/td>\n<td>Insulin sensitivity, lipolysis, adipogenesis<\/td>\n<td>Preclinical + early human studies<\/td>\n<\/tr>\n<tr>\n<td>Inflammation<\/td>\n<td>CD38, NF-\u03baB pathway<\/td>\n<td>Preclinical<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-48038701\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>NAD+ vs. NMN and NR Precursors \u2014 A Research Perspective<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Compound<\/strong><\/td>\n<td><strong>What is<\/strong><\/td>\n<td><strong>The Mechanism of NAD+ Regeneration<\/strong><\/td>\n<\/tr>\n<tr>\n<td>NAD+<\/td>\n<td>Direct coenzyme<\/td>\n<td>Direct delivery \u2014 highest in vitro biological activity; limited cellular permeability<\/td>\n<\/tr>\n<tr>\n<td>NMN<\/td>\n<td>Mononucleotide<\/td>\n<td>Salvage pathway (NMNAT enzymes)<\/td>\n<\/tr>\n<tr>\n<td>NR<\/td>\n<td>Nucleoside<\/td>\n<td>Salvage pathway (NRK enzymes)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>For <strong>in vitro<\/strong> research (cell cultures), direct NAD+ is preferred\u2014it allows for precise control of the concentration in the medium without relying on enzymatic conversion. For <strong>in vivo<\/strong> models, precursors (NMN, NR) are typically used to ensure better bioavailability.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-413662065\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Technical Specifications<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Parameter<\/strong><\/td>\n<td><strong>Value<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Contents per package<\/td>\n<td>500 mg<\/td>\n<\/tr>\n<tr>\n<td>Form<\/td>\n<td>Freeze-dried powder (vial)<\/td>\n<\/tr>\n<tr>\n<td>Purity<\/td>\n<td>\u226598% (HPLC-verified)<\/td>\n<\/tr>\n<tr>\n<td>Recommended solvent<\/td>\n<td>Deionized water or PBS (pH 7.4)<\/td>\n<\/tr>\n<tr>\n<td>Storage \u2013 freeze-dried<\/td>\n<td>\u221220 \u00b0C, protect from light and moisture<\/td>\n<\/tr>\n<tr>\n<td>Storage \u2013 after reconstitution<\/td>\n<td>2\u20138 \u00b0C, use within 7 days; for longer storage, \u221280 \u00b0C<\/td>\n<\/tr>\n<tr>\n<td>Stability<\/td>\n<td>NAD+ is sensitive to hydrolysis at higher pH levels; maintain a pH of \u2264 7.4<\/td>\n<\/tr>\n<tr>\n<td>Intended Use<\/td>\n<td>Exclusively preclinical\/laboratory research<\/td>\n<\/tr>\n<tr>\n<td>Age Restriction<\/td>\n<td>18+<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1088656245\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Frequently Asked Questions About NAD+ (FAQ)<\/h2>\n<div class=\"accordion\">\n\t<div id=\"accordion-309194196\" class=\"accordion-item\">\n\t\t<a id=\"accordion-309194196-label\" class=\"accordion-title plain\" href=\"#accordion-item-what-is-nad+,-and-why-is-it-the-focus-of-aging-research?\" aria-expanded=\"false\" aria-controls=\"accordion-309194196-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>What is NAD+, and why is it the focus of aging research?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-309194196-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-309194196-label\">\n\t\t\t\nNAD+ is a coenzyme essential for mitochondrial respiration and a substrate for sirtuins\u2014enzymes that regulate biological aging. NAD+ levels decline by up to 50% with age, which correlates with impaired cellular repair mechanisms. Research on NAD+ supplementation is one of the most active areas of longevity bioscience.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-1727427740\" class=\"accordion-item\">\n\t\t<a id=\"accordion-1727427740-label\" class=\"accordion-title plain\" href=\"#accordion-item-what-is-the-difference-between-nad+-and-nadh?\" aria-expanded=\"false\" aria-controls=\"accordion-1727427740-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>What is the difference between NAD+ and NADH?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-1727427740-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-1727427740-label\">\n\t\t\t\nNAD+ is the oxidized form (electron acceptor), while NADH is the reduced form (electron donor). NAD+ is generally required for research protocols\u2014it serves as a substrate for sirtuins and PARP enzymes.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-632770402\" class=\"accordion-item\">\n\t\t<a id=\"accordion-632770402-label\" class=\"accordion-title plain\" href=\"#accordion-item-why-not-use-a-precursor-(nmn\/nr)-instead-of-nad+-directly?\" aria-expanded=\"false\" aria-controls=\"accordion-632770402-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>Why not use a precursor (NMN\/NR) instead of NAD+ directly?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-632770402-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-632770402-label\">\n\t\t\t\nFor in vitro experiments (cell cultures, enzyme assays), direct NAD+ is a more precise tool\u2014it eliminates the variability associated with enzymatic conversion and allows for precise control of concentration.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-2979734089\" class=\"accordion-item\">\n\t\t<a id=\"accordion-2979734089-label\" class=\"accordion-title plain\" href=\"#accordion-item-how-should-nad+-be-stored?\" aria-expanded=\"false\" aria-controls=\"accordion-2979734089-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>How should NAD+ be stored?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-2979734089-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-2979734089-label\">\n\t\t\t\nStore the lyophilized powder at \u221220 \u00b0C, protected from light and moisture. After reconstitution, store at 2\u20138 \u00b0C (use within 7 days) or at \u221280 \u00b0C for long-term storage.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-2014005425\" class=\"accordion-item\">\n\t\t<a id=\"accordion-2014005425-label\" class=\"accordion-title plain\" href=\"#accordion-item-is-nad+-intended-for-human-consumption?\" aria-expanded=\"false\" aria-controls=\"accordion-2014005425-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>Is NAD+ intended for human consumption?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-2014005425-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-2014005425-label\">\n\t\t\t\nNo. The NAD+ available on jacked.sk is intended exclusively for scientific research and laboratory use.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1769873053\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t<div class=\"is-border\"\n\t\tstyle=\"border-color:#fe5000;border-width:1px 1px 1px 1px;\">\n\t<\/div>\n\t\t\t\n<h4>\u26a0\ufe0f Final Disclaimer<\/h4>\n<p>NAD+ available at jacked.sk is a research compound intended for laboratory and preclinical studies. It is not a drug, a dietary supplement, or a cosmetic product. It has not been approved by any regulatory authority for human use. The seller is not liable for any use that violates these terms and conditions.<br \/>\n\t\t<\/div>\n\t\t\t\t\n<style>\n#col-1769873053 > .col-inner {\n  padding: 0.5rem 0.5rem 0.5rem 0.5rem;\n}\n<\/style>\n\t<\/div>\n\n\t\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme present in all living cells. It serves as a key electron carrier in the mitochondrial electron transport chain and as a substrate for sirtuins (SIRT1\u20137) and PARP enzymes responsible for DNA repair. NAD+ levels decline with age by up to 50% by middle age, making it a subject of intensive research in the fields of aging, mitochondrial biology, and neuroprotection.  <\/p>\n<ul>\n<li>Purity <strong>\u2265 98%<\/strong> \u2013 Each batch verified by HPLC; COA available upon request<\/li>\n<li>Freeze-dried powder, store at \u221220 \u00b0C<\/li>\n<li>Shipped within 48 hours<\/li>\n<\/ul>\n","protected":false},"featured_media":9566,"template":"","meta":[],"product_brand":[],"product_cat":[154],"product_tag":[],"class_list":["post-9427","product","type-product","status-publish","has-post-thumbnail","product_cat-research-on-longevity-and-the-slowing-of-aging","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product\/9427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/media\/9566"}],"wp:attachment":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/media?parent=9427"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_brand?post=9427"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_cat?post=9427"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_tag?post=9427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}