{"id":9425,"date":"2026-08-21T10:44:29","date_gmt":"2026-08-21T08:44:29","guid":{"rendered":"https:\/\/dev.jacked.sk\/uncategorized\/5-amino-1mq-50-mg\/"},"modified":"2026-08-21T14:11:31","modified_gmt":"2026-08-21T12:11:31","slug":"5-amino-1mq-50-mg","status":"publish","type":"product","link":"https:\/\/dev.jacked.sk\/en\/research-on-weight-loss-and-metabolism\/5-amino-1mq-50-mg\/","title":{"rendered":"5-Amino-1MQ 50 mg"},"content":{"rendered":"<div class=\"row read-more\"  id=\"row-1985828437\">\n\n\t<div id=\"col-1336420150\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h1>5-Amino-1MQ 50 mg \u2014 Selective NNMT Inhibitor for Research in Metabolism and Adipocyte Biology<\/h1>\n<p>\u26a0\ufe0f <strong>Warning:<\/strong> This product is intended exclusively for scientific research and laboratory use. It is not intended for human or veterinary use, nor for the diagnosis, treatment, or prevention of any disease. Sale restricted to individuals over the age of 18.<br \/>\n<strong>5-amino-1MQ<\/strong> (5-amino-1-methylquinolinium) represents a new type of research tool in the field of metabolic biology. Unlike peptide compounds that specifically activate receptors (GLP-1, GIP), 5-amino-1MQ acts <strong>intracellularly as an enzyme inhibitor<\/strong> \u2014it blocks NNMT (nicotinamide N-methyltransferase), an enzyme identified as a key regulator of fat metabolism, energy expenditure, and cell biology.<br \/>\nIt was first characterized by a research group at the University of Texas Health Science Center and represents pharmacological confirmation of the genetic findings of the Kraus group, which demonstrated that NNMT knockout in mice leads to resistance to diet-induced obesity.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-541488062\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Chemical Identity<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Parameter<\/strong><\/td>\n<td><strong>Value<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Full name<\/td>\n<td>5-amino-1-methylquinolinium<\/td>\n<\/tr>\n<tr>\n<td>Abbreviation<\/td>\n<td>5-amino-1MQ<\/td>\n<\/tr>\n<tr>\n<td>Compound Type<\/td>\n<td>Small-molecule NNMT inhibitor (non-peptide)<\/td>\n<\/tr>\n<tr>\n<td>IC\u2085\u2080 against NNMT<\/td>\n<td>1.2 \u03bcM<\/td>\n<\/tr>\n<tr>\n<td>Form<\/td>\n<td>Freeze-dried powder<\/td>\n<\/tr>\n<tr>\n<td>Purity<\/td>\n<td>\u226598% (HPLC)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-2129456453\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>What is NNMT, and why is it a research goal?<\/h2>\n<p>NNMT (nicotinamide N-methyltransferase) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, resulting in the formation of 1-methylnicotinamide (1-MNA). This reaction has implications on two levels: <\/p>\n<ul>\n<li><strong>It diverts nicotinamide from the NAD+ salvage pathway<\/strong> \u2192 reducing the intracellular capacity to regenerate NAD+<\/li>\n<li><strong>Depletes SAM for methylation<\/strong> \u2192 SAM is a universal donor of methyl groups for epigenetic modifications (DNA and histone methylation)<\/li>\n<\/ul>\n<p>NNMT is overexpressed in the adipose tissue of obese individuals and in cases of insulin resistance, making it the subject of intensive research as a therapeutic target for metabolic diseases.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-804285033\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Mechanism of Action of 5-Amino-1MQ<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-786866897\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3>The NAD+ Axis<\/h3>\n<p>By blocking NNMT, nicotinamide is not diverted to the formation of 1-MNA but remains available for the NAD+ salvage pathway (NAMPT):<\/p>\n<ul>\n<li>\u2191 intracellular NAD+<\/li>\n<li>\u2191 sirtuin activity (SIRT1\/SIRT3)<\/li>\n<li>\u2191 mitochondrial biogenesis<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1679478374\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3>SAM \/ Epigenetics<\/h3>\n<p>Without nicotinamide methylation, SAM is not degraded and remains available for epigenetic methylation:<\/p>\n<ul>\n<li>\u2191 SAM available for DNA and histone methylation<\/li>\n<li>Modulation of Gene Expression in Adipocytes<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1702646565\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<strong>In vitro and in vivo (animal models) results:<\/strong><\/p>\n<ul>\n<li>Increase in intracellular NAD+ levels in adipocytes<\/li>\n<li>Activation of thermogenesis in white adipose tissue (browning effect)<\/li>\n<li>Reduction in adipogenesis and adipocyte size<\/li>\n<li>Improved insulin sensitivity (GLUT4 expression)<\/li>\n<li>Preserving Muscle Mass While Reducing Body Fat<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1146923377\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Key Preclinical Studies<\/h2>\n<h3>Neelakantan et al. (2018) \u2014 Biochemical Pharmacology <\/h3>\n<p>Selective, membrane-permeable, small-molecule NNMT inhibitors reverse obesity induced by a high-fat diet in mice.<\/p>\n<ul>\n<li>Model: diet-induced obese mice (C57BL\/6), 11 days, 20 mg\/kg 3 times daily s.c.<\/li>\n<li>A significant reduction in body weight (p &lt; 0.05) and white adipose tissue mass (p &lt; 0.01) without any change in food intake<\/li>\n<li>A reduction in plasma cholesterol (p &lt; 0.05) and adipocyte size (p &lt; 0.0001)<\/li>\n<li>Selectivity: IC\u2085\u2080 = 1.2 \u03bcM against NNMT<\/li>\n<\/ul>\n<h3>Sampson et al. (2021) \u2014 Scientific Reports<\/h3>\n<p>Combination of an NNMT inhibitor with dietary intervention in obese mice. The combination of 5-amino-1MQ and a low-calorie diet significantly reduced body weight, fat mass, liver fat content, and hepatic steatosis beyond the effects of either intervention alone. <\/p>\n<h3>Dimet-Wiley et al. (2024) \u2014 Scientific Reports<\/h3>\n<p>NNMT inhibition mimics and enhances the effects of exercise on muscle function in aged mice. The combination of an NNMT inhibitor and exercise resulted in a 60% improvement in grip strength compared with sedentary controls; 5-amino-1MQ alone produced a 40% improvement\u2014suggesting a mechanism distinct from exercise.<br \/>\n\u26a0\ufe0f <strong>Important:<\/strong> None of these studies were conducted in humans. All results come from preclinical animal models. The transferability to human biology has not been confirmed.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-556881412\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>5-Amino-1MQ vs. GLP-1 Agonists \u2014 A Research Perspective<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Parameter<\/strong><\/td>\n<td><strong>5-amino-1MQ<\/strong><\/td>\n<td><strong>GLP-1 agonists<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Mechanism<\/td>\n<td>NNMT inhibition (intracellular)<\/td>\n<td>Receptor agonism (extracellular)<\/td>\n<\/tr>\n<tr>\n<td>Target organ<\/td>\n<td>Adipose tissue, muscles<\/td>\n<td>Pancreas, brain, GI tract<\/td>\n<\/tr>\n<tr>\n<td>Effect on appetite<\/td>\n<td>No (in vitro data)<\/td>\n<td>Yes (central effect)<\/td>\n<\/tr>\n<tr>\n<td>Maintenance of Muscle Mass<\/td>\n<td>Yes (animal models)<\/td>\n<td>Partially<\/td>\n<\/tr>\n<tr>\n<td>Clinical experience<\/td>\n<td>None (preclinical only)<\/td>\n<td>Extensive Phase 3 \/ Approved<\/td>\n<\/tr>\n<tr>\n<td>Effect on NAD+<\/td>\n<td>Yes (via the salvage pathway)<\/td>\n<td>No<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>5-amino-1MQ is a tool of research interest for an alternative approach to metabolic biology\u2014the combination of NNMT inhibition with incretin mimetics is an active research hypothesis.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-2107237145\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Technical Specifications<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Parameter<\/strong><\/td>\n<td><strong>Value<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Contents per package<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>Form<\/td>\n<td>Freeze-dried powder (vial)<\/td>\n<\/tr>\n<tr>\n<td>Purity<\/td>\n<td>\u226598% (HPLC-verified)<\/td>\n<\/tr>\n<tr>\n<td>Recommended solvent<\/td>\n<td>DMSO (for stock solution), then dilute with PBS<\/td>\n<\/tr>\n<tr>\n<td>Storage \u2013 freeze-dried<\/td>\n<td>\u221220 \u00b0C, protect from light<\/td>\n<\/tr>\n<tr>\n<td>Storage \u2013 after reconstitution<\/td>\n<td>\u221220 \u00b0C in aliquots; avoid repeated thawing<\/td>\n<\/tr>\n<tr>\n<td>Intended Use<\/td>\n<td>Exclusively preclinical\/laboratory research<\/td>\n<\/tr>\n<tr>\n<td>Age Restriction<\/td>\n<td>18+<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-117163099\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Frequently Asked Questions About 5-Amino-1MQ (FAQ)<\/h2>\n<div class=\"accordion\">\n\t<div id=\"accordion-2942948626\" class=\"accordion-item\">\n\t\t<a id=\"accordion-2942948626-label\" class=\"accordion-title plain\" href=\"#accordion-item-what-is-5-amino-1mq,-and-what-does-it-do?\" aria-expanded=\"false\" aria-controls=\"accordion-2942948626-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>What is 5-amino-1MQ, and what does it do?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-2942948626-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-2942948626-label\">\n\t\t\t\n5-amino-1MQ is a small-molecule inhibitor of the NNMT enzyme. By blocking NNMT, it redirects nicotinamide to the NAD+ salvage pathway (\u2191 NAD+) and preserves SAM for methylation in adipocytes, leading to the modulation of fat metabolism in preclinical models.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-3597507690\" class=\"accordion-item\">\n\t\t<a id=\"accordion-3597507690-label\" class=\"accordion-title plain\" href=\"#accordion-item-is-5-amino-1mq-a-peptide?\" aria-expanded=\"false\" aria-controls=\"accordion-3597507690-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>Is 5-amino-1MQ a peptide?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-3597507690-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-3597507690-label\">\n\t\t\t\nNo. Unlike BPC-157, TB-500, or SS-31, 5-amino-1MQ is a small-molecule organic inhibitor (a quinoline salt)\u2014not a peptide. Jacked.sk classifies it as a research compound.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-2156548902\" class=\"accordion-item\">\n\t\t<a id=\"accordion-2156548902-label\" class=\"accordion-title plain\" href=\"#accordion-item-are-there-any-clinical-studies-in-humans-involving-5-amino-1mq?\" aria-expanded=\"false\" aria-controls=\"accordion-2156548902-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>Are there any clinical studies in humans involving 5-amino-1MQ?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-2156548902-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-2156548902-label\">\n\t\t\t\nAs of July 2026, no human clinical studies had been published. All available data come from preclinical animal models. The applicability of these results to humans has not been confirmed.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-1122798228\" class=\"accordion-item\">\n\t\t<a id=\"accordion-1122798228-label\" class=\"accordion-title plain\" href=\"#accordion-item-how-does-5-amino-1mq-differ-from-glp-1-agonists?\" aria-expanded=\"false\" aria-controls=\"accordion-1122798228-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>How does 5-amino-1MQ differ from GLP-1 agonists?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-1122798228-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-1122798228-label\">\n\t\t\t\nGLP-1 agonists reduce appetite via the central nervous system and are clinically approved. 5-amino-1MQ acts through a different mechanism (NNMT inhibition, intracellular) without affecting appetite in preclinical models\u2014a distinction of research interest.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-252009265\" class=\"accordion-item\">\n\t\t<a id=\"accordion-252009265-label\" class=\"accordion-title plain\" href=\"#accordion-item-how-should-5-amino-1mq-be-stored?\" aria-expanded=\"false\" aria-controls=\"accordion-252009265-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>How should 5-amino-1MQ be stored?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-252009265-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-252009265-label\">\n\t\t\t\nFreeze-dried powder at \u221220 \u00b0C, protected from light. We recommend using DMSO for the stock solution, followed by dilution into an aqueous buffer (PBS). Store reconstituted solutions in aliquots at \u221220 \u00b0C.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1441997552\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t<div class=\"is-border\"\n\t\tstyle=\"border-color:#fe5000;border-width:1px 1px 1px 1px;\">\n\t<\/div>\n\t\t\t\n<h4>\u26a0\ufe0f Final Disclaimer<\/h4>\n<p>5-amino-1MQ, available at jacked.sk, is a research compound intended exclusively for laboratory and preclinical studies. It is not approved by any regulatory authority (FDA, EMA, \u0160\u00daKL) for human use. It is not a drug, nor is it a dietary supplement. The seller is not liable for any use that violates these terms and conditions.<br \/>\n\t\t<\/div>\n\t\t\t\t\n<style>\n#col-1441997552 > .col-inner {\n  padding: 0.5rem 0.5rem 0.5rem 0.5rem;\n}\n<\/style>\n\t<\/div>\n\n\t\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>5-amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase)\u2014a metabolic regulator expressed primarily in adipose tissue. By inhibiting NNMT, it redirects nicotinamide back into the NAD\u207a salvage pathway, thereby increasing intracellular NAD\u207a levels and modulating SAM-dependent methylation in adipocytes. In a key preclinical study (Neelakantan et al., 2018), it reduced body weight and white adipose tissue mass in obese mice without altering food intake.  <\/p>\n<ul>\n<li>Purity <strong>\u2265 98%<\/strong> \u2013 Each batch verified by HPLC; COA available upon request<\/li>\n<li>Freeze-dried powder, store at \u221220 \u00b0C<\/li>\n<li>Shipped within 48 hours<\/li>\n<\/ul>\n","protected":false},"featured_media":0,"template":"","meta":[],"product_brand":[],"product_cat":[153],"product_tag":[],"class_list":["post-9425","product","type-product","status-publish","product_cat-research-on-weight-loss-and-metabolism","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product\/9425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/media?parent=9425"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_brand?post=9425"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_cat?post=9425"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_tag?post=9425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}