{"id":782,"date":"2017-05-12T09:03:27","date_gmt":"2017-05-12T07:03:27","guid":{"rendered":"https:\/\/jacked.sk\/obchod\/ghrp-6\/"},"modified":"2026-08-21T14:33:18","modified_gmt":"2026-08-21T12:33:18","slug":"ghrp-6-5mg","status":"publish","type":"product","link":"https:\/\/dev.jacked.sk\/en\/research-on-muscle-growth\/ghrp-6-5mg\/","title":{"rendered":"GHRP-6 5 mg"},"content":{"rendered":"
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H1: GHRP-6 5 mg \u2013 Ghrelin Receptor Agonist for Research on GH Secretion<\/h1>\n

\u26a0\ufe0f Warning:<\/strong> GHRP-6 sold on jacked.sk is intended exclusively for scientific research purposes<\/strong> (research use only<\/em>). It is not intended for human use; it is not a drug, dietary supplement, or cosmetic product. Intended only for qualified researchers.
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What is GHRP-6? Scientific Description <\/h2>\n

GHRP-6 (Growth Hormone-Releasing Peptide-6) is a<\/strong> synthetic hexapeptide<\/strong> belonging to the group of GH secretagogues\u2014compounds studied for their ability to stimulate the secretion of growth hormone (GH) from the pituitary gland. The abbreviation \u201c6\u201d refers to the six amino acid residues that make up its structure: His-D-Trp-Ala-Trp-D-Phe-Lys-NH\u2082<\/strong>.
\nGHRP-6 was one of the first synthetic GH secretagogues developed as part of research on the ghrelin axis and is among the most extensively preclinically studied peptide compounds in this category. Its research profile is characterized by a potent GH-releasing effect combined with significant activation of the ghrelin receptor, which is relevant to research on metabolism and appetite.
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Chemical Structure and Properties<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/strong><\/td>\nValue<\/strong><\/td>\n<\/tr>\n
Sequence<\/td>\nHis-D-Trp-Ala-Trp-D-Phe-Lys-NH\u2082<\/td>\n<\/tr>\n
Class<\/td>\nSynthetic hexapeptide, GH secretagogue<\/td>\n<\/tr>\n
CAS Number<\/td>\n87616-84-0<\/td>\n<\/tr>\n
Molecular weight<\/td>\n873.0 Da<\/td>\n<\/tr>\n
Form (jacked.sk)<\/td>\n5 mg freeze-dried powder<\/td>\n<\/tr>\n
Purity<\/td>\n\u226598% (HPLC-verified)<\/td>\n<\/tr>\n
Storage<\/td>\n\u221220 \u00b0C; protect from light and moisture<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Mechanism of action \u2013 ghrelin receptor GHS-R1a<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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GH secretion and the pituitary axis<\/h3>\n

GHRP-6 acts as an agonist of the GHS-R1a receptor<\/strong> (Growth Hormone Secretagogue Receptor 1a)\u2014a receptor identical to the receptor for endogenous ghrelin. Binding to GHS-R1a in somatotropic cells of the anterior pituitary lobe stimulates the pulsatile release of growth hormone. Preclinical studies consistently document the potent GH-secreting effect of GHRP-6, comparable to that of GHRP-2 (Bowers et al., Endocrinology<\/em>, 1984).
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The Ghrelin Effect and Appetite Research<\/h3>\n

Unlike the more selective Ipamorelin, GHRP-6 exhibits a pronounced ghrelin effect<\/strong> \u2014the activation of ghrelin signaling pathways in the hypothalamus. Ghrelin is an endogenous \u201chunger hormone\u201d that regulates energy balance. Preclinical studies in animal models have observed a significant increase in food intake following administration of GHRP-6, making this peptide a subject of research in the field of cachexia and metabolic disorders associated with weight loss (Wren et al., Endocrinology<\/em>, 2000).
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Areas of Scientific Research on GHRP-6<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Research on Growth Hormone<\/h3>\n

Preclinical and early clinical studies document the strong GH-secreting activity of GHRP-6. The research focused on the pulsatile pattern of GH secretion, the synergistic effect with GHRH (growth hormone-releasing hormone), and the subsequent increase in IGF-1 (insulin-like growth factor 1) in the liver. GHRP-6 has been used in diagnostic protocols to test pituitary GH reserve.
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Research on Cachexia and Appetite<\/h3>\n

The activation of the ghrelin axis by GHRP-6 is the subject of research in the context of cachexia<\/strong> \u2014a severe metabolic syndrome characterized by involuntary loss of muscle mass and appetite in chronic diseases (cancer, heart failure, AIDS). Preclinical models suggest that GHRP-6 has the potential to increase food intake and maintain body weight. These findings form the basis for research interest, although there is currently no clinical approval.
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Cortisol and Prolactin \u2013 Research Context<\/h3>\n

Preclinical studies have shown that GHRP-6 (similar to GHRP-2) simultaneously stimulates the secretion of cortisol and prolactin<\/strong> \u2014unlike the selective Ipamorelin, which does not exhibit these secondary secretions. This research difference is relevant in comparative studies of GH secretagogues and influences the selection of a peptide for specific research protocols.
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Comparison of GH Peptides \u2013 GHRP-6, GHRP-2, and Ipamorelin<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Property<\/strong><\/td>\nGHRP-6<\/strong><\/td>\nGHRP-2<\/strong><\/td>\nIpamorelin<\/strong><\/td>\n<\/tr>\n
Class<\/td>\nHexapeptide<\/td>\nHexapeptide<\/td>\nPentapeptide<\/td>\n<\/tr>\n
GH secretion (level)<\/td>\nStrong<\/td>\nStrong<\/td>\nMild to moderate<\/td>\n<\/tr>\n
Ghrelin Effect<\/td>\nStrong<\/strong> (significant appetite stimulation)<\/td>\nMilder<\/td>\nMinimal<\/td>\n<\/tr>\n
Cortisol\/Prolactin<\/td>\n\u2191 Increases<\/td>\n\u2191 Increases<\/td>\nDoes not increase (selective)<\/td>\n<\/tr>\n
Selectivity<\/td>\nLow<\/td>\nLow<\/td>\nHigh<\/strong><\/td>\n<\/tr>\n
Research Interests<\/td>\nCachexia, appetite, GH<\/td>\nGH, metabolism<\/td>\nSelective GH secretion<\/td>\n<\/tr>\n
Contents (jacked.sk)<\/td>\n5 mg<\/td>\n5 mg<\/td>\n5 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Technical Specifications<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/strong><\/td>\nValue<\/strong><\/td>\n<\/tr>\n
Contents<\/td>\n5 mg freeze-dried powder<\/td>\n<\/tr>\n
Purity<\/td>\n\u226598% (HPLC)<\/td>\n<\/tr>\n
CAS Number<\/td>\n87616-84-0<\/td>\n<\/tr>\n
Molecular weight<\/td>\n873.0 Da<\/td>\n<\/tr>\n
Appearance<\/td>\nWhite freeze-dried powder<\/td>\n<\/tr>\n
Storage<\/td>\n\u221220 \u00b0C (long-term), 4 \u00b0C (short-term, up to 4 weeks)<\/td>\n<\/tr>\n
Sterility<\/td>\nThis product is not sterile\u2014it is not intended for injection or human use<\/td>\n<\/tr>\n
Intended Use<\/td>\nFor scientific research purposes only<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Frequently Asked Questions About GHRP-6 (FAQ)<\/h2>\n
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