{"id":3376,"date":"2023-07-13T22:19:48","date_gmt":"2023-07-13T20:19:48","guid":{"rendered":"https:\/\/jacked.sk\/obchod\/nootropic-peptide-semax\/"},"modified":"2026-08-21T14:22:59","modified_gmt":"2026-08-21T12:22:59","slug":"nootropic-peptide-semax","status":"publish","type":"product","link":"https:\/\/dev.jacked.sk\/en\/research-on-cognitive-functions\/nootropic-peptide-semax\/","title":{"rendered":"Semax 20 mg"},"content":{"rendered":"
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H1: Semax 20 mg \u2013 A Neuropeptide for Research on Cognitive Functions and BDNF<\/h1>\n

\u26a0\ufe0f Warning:<\/strong> Semax sold on jacked.sk is intended exclusively for scientific research purposes<\/strong> (research use only<\/em>). It is not intended for human use; it is not a drug, dietary supplement, or cosmetic product. Intended only for qualified researchers.
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What is Semax? Scientific description and origin <\/h2>\n

Semax is a synthetic heptapeptide with the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro<\/strong>. It is an analog of the adrenocorticotropic hormone (ACTH) fragment (4-7) with a Pro-Gly-Pro extension, which, according to research data, provides it with increased metabolic stability compared to the original fragment.
\nSemax was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences (IMGen RAN)<\/strong> in Moscow during the 1990s. In the Russian Federation, Semax is registered as a medicinal product\u2014however, this registration is not valid in European Union countries or in the United States (FDA). In the context of international research, Semax is classified among the nootropic neuropeptides<\/strong> being studied for their potential neuroprotective and cognitive properties.
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Chemical Structure and Properties<\/h2>\n\n\n\n\n\n\n\n\n\n
Parameter<\/strong><\/td>\nValue<\/strong><\/td>\n<\/tr>\n
Sequence<\/td>\nMet-Glu-His-Phe-Pro-Gly-Pro<\/td>\n<\/tr>\n
Class<\/td>\nSynthetic heptapeptide, an analog of ACTH(4-7)<\/td>\n<\/tr>\n
Form (jacked.sk)<\/td>\n20 mg freeze-dried powder<\/td>\n<\/tr>\n
Purity<\/td>\n\u226598% (HPLC-verified)<\/td>\n<\/tr>\n
Storage<\/td>\n\u221220 \u00b0C; protect from light and moisture<\/td>\n<\/tr>\n
Administration in Research<\/td>\nIntranasal Administration (Research Protocols)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

The Pro-Gly-Pro extension increases the peptide\u2019s resistance to enzymatic degradation, which is relevant from a research perspective for bioavailability studies. The intranasal route of administration used in preclinical protocols is the subject of research, particularly due to its potential to cross the blood-brain barrier (BBB).
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Mechanism of Action \u2013 How Semax Works in Research<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Modulation of ACTH Receptors<\/h3>\n

Semax exhibits affinity for adrenocorticotropic hormone receptors, and preclinical studies suggest that its mechanism of action differs from that of the full ACTH molecule\u2014it does not involve the glucocorticoid axis. Research is primarily focused on its activity in the central nervous system.
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Research on BDNF Expression<\/h3>\n

One of the most actively studied areas is the effect of Semax on the expression of BDNF (Brain-Derived Neurotrophic Factor)<\/strong> \u2014a neurotrophic factor essential for the survival, growth, and differentiation of neurons, as well as for synaptic plasticity. Preclinical studies in animal models have observed increased BDNF levels following Semax administration (Dolotov et al., 2006, Journal of Molecular Neuroscience<\/em>). Low levels of BDNF are associated in the research literature with conditions such as depression, Alzheimer\u2019s disease, and cognitive decline\u2014making BDNF modulation an active area of neuroscience research.
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Semax’s Areas of Scientific Research<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Neuroprotection and Ischemic Brain Injury<\/h3>\n

Preclinical studies in animal models suggest that Semax has neuroprotective potential in ischemic brain injury. The research observed a reduction in the extent of the infarct area and modulation of inflammatory markers following experimental cerebral ischemia (Gusev et al., 2018, Molecular Genetics, Microbiology and Virology<\/em>). These results pertain exclusively to animal models.
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Research on Memory and Learning<\/h3>\n

Studies in rodent models have observed the potential effect of Semax on learning and memory consolidation processes. Researchers noted improved performance in spatial navigation tests (Maisov et al.). The mechanism is associated with the modulation of the dopaminergic and serotonergic systems in the hippocampus.
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Research on ADHD-like Conditions<\/h3>\n

Research in the field of neuroscience has examined Semax in the context of ADHD-like phenotypes in animal models. Preclinical data suggest modulation of attention and impulsive behavior, which represents a fundamental area of research interest without clinical application in the EU.
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Technical Specifications<\/h2>\n\n\n\n\n\n\n\n\n\n
Parameter<\/strong><\/td>\nValue<\/strong><\/td>\n<\/tr>\n
Contents<\/td>\n20 mg freeze-dried powder<\/td>\n<\/tr>\n
Purity<\/td>\n\u226598% (HPLC)<\/td>\n<\/tr>\n
Appearance<\/td>\nWhite to grayish-white lyophilized powder<\/td>\n<\/tr>\n
Storage<\/td>\n\u221220 \u00b0C (long-term), 4 \u00b0C (short-term, up to 4 weeks)<\/td>\n<\/tr>\n
Sterility<\/td>\nThis product is not sterile\u2014it is not intended for injection or human use<\/td>\n<\/tr>\n
Intended Use<\/td>\nFor scientific research purposes only<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Frequently Asked Questions About Semax (FAQ)<\/h2>\n
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