{"id":3138,"date":"2023-04-17T01:34:26","date_gmt":"2023-04-16T23:34:26","guid":{"rendered":"https:\/\/jacked.sk\/obchod\/pt-141\/"},"modified":"2026-08-21T14:29:25","modified_gmt":"2026-08-21T12:29:25","slug":"pt-141-10mg","status":"publish","type":"product","link":"https:\/\/dev.jacked.sk\/en\/research-on-sun-exposure-and-sexual-health\/pt-141-10mg\/","title":{"rendered":"PT-141 10 mg"},"content":{"rendered":"<div class=\"row read-more\"  id=\"row-1631753564\">\n\n\t<div id=\"col-748793431\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h1>PT-141 10 mg (Bremelanotide) \u2013 A Melanocortin Peptide for Research on Sexual Function<\/h1>\n<p>\u26a0\ufe0f <strong>Legal Notice:<\/strong> PT-141 is intended solely for scientific and research purposes. It is not intended for human use as a medication, dietary supplement, or cosmetic product. Sale is restricted to individuals over the age of 18.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1337434708\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>What is PT-141 (Bremelanotide)?<\/h2>\n<p>PT-141, scientifically known as <strong>bremelanotide<\/strong>, is a synthetic cyclic heptapeptide derived from Melanotan-2 (MT-2). It is formed by the enzymatic cleavage of N-terminal acetyl-norleucine from the MT-2 molecule, thereby altering its receptor-binding profile and biological properties.<br \/>\nUnlike most compounds studied in the field of sexual function, PT-141 does not primarily affect the vascular system. Its mechanism of action, which is of scientific interest, is <strong>central<\/strong> \u2014it acts through receptors in the brain, specifically in the hypothalamus and the limbic system. It is precisely this property that makes PT-141 a subject of scientific interest in areas where peripheral (vascular) mechanisms are insufficient.<br \/>\nPT-141 belongs to the group of melanocortin peptides\u2014compounds that bind to various subtypes of melanocortin receptors (MC1R through MC5R) and influence a wide range of physiological processes, from skin pigmentation to energy metabolism.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1982162483\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Mechanism of Action in Research<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1355364006\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3>Selective activation of the MC4R receptor<\/h3>\n<p>The key mechanism of PT-141 is its <strong>selective agonist activity at the melanocortin receptor 4 (MC4R)<\/strong>. This receptor is primarily expressed in the hypothalamus and limbic system\u2014areas of the brain that are the focus of research related to the central regulation of sexual motivation and response.<br \/>\nPreclinical studies demonstrate that activation of MC4R in the hypothalamus influences signaling cascades associated with sexual behavior in animal models. This mechanism is independent of peripheral vasodilation, which distinguishes it from PDE5 inhibitors (sildenafil, tadalafil) studied for erectile dysfunction.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-2130968938\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3>Differences from Melanotan-2 and PDE5 inhibitors<\/h3>\n<p>PT-141 and its precursor, Melanotan-2 (MT-2), differ significantly in their receptor profiles:<\/p>\n<ul>\n<li><strong>MT-2<\/strong> activates several receptors at once: MC1R (pigmentation), MC3R (energy metabolism), and MC4R (central sexual function). This also results in significant melanogenesis (darkening of the skin). <\/li>\n<li>In research models, <strong>PT-141<\/strong> exhibits <strong>higher selectivity for MC4R<\/strong> with minimal effect on MC1R, which means there is no significant melanogenesis when used in research.<\/li>\n<\/ul>\n<p>Unlike PDE5 inhibitors, which dilate blood vessels in the genital organs and rely on a peripheral vascular mechanism, PT-141 acts at the central level\u2014through neural pathways in the brain.<br \/>\n<em>Source: Pfaus JG. et al., Current Opinion in Pharmacology (2007); Molinoff PB. et al., Annals of the New York Academy of Sciences (2003)  <\/em><br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1587141040\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Regulatory Context \u2013 FDA and Vyleesi\u00ae<\/h2>\n<p>One of the research-related milestones for PT-141 is <strong>the FDA\u2019s approval of the drug Vyleesi\u00ae (bremelanotide 1.75 mg)<\/strong> in June 2019. This marks the first-ever FDA approval for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women via a central mechanism. Vyleesi\u00ae is a subcutaneous injectable formulation of bremelanotide in a pharmaceutical dose.<br \/>\nThis approval confirms the scientifically documented mechanism of the MC4R agonist in the central regulation of sexual function and provides an important foundation for further academic research on the molecule.<br \/>\n<strong>Important Note:<\/strong> PT-141 10 mg from jacked.sk is a research-grade compound intended exclusively for laboratory and scientific research. It is not identical to the pharmaceutical drug Vyleesi\u00ae and is not intended for human therapeutic use.<br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-991527611\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Areas of Scientific Research on PT-141<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-452307427\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3>Research on Sexual Dysfunction in Women (HSDD)<\/h3>\n<p>Clinical studies with bremelanotide (which led to the approval of Vyleesi\u00ae) document a statistically significant increase in sexual desire and a reduction in personal distress in premenopausal women diagnosed with HSDD. These clinical data provide a basis for further research on MC4R agonists in the field of sexual neurophysiology.<br \/>\nThe RECONNECT study (two parallel Phase 3 trials, n &gt;,1200 women) demonstrated a statistically significant difference compared to placebo in the primary endpoints (FSDS-DAO and FSFI desire domain scores).<br \/>\n<em>Source: Simon JA. et al., Obstetrics &#038; Gynecology (2019) <\/em><br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-2033884850\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h3>Preclinical Research on Male Sexual Function<\/h3>\n<p>Preclinical studies in rat models have examined the effect of MC4R agonism on erectile function via central pathways. The research documented an increase in the frequency of erectile events following systemic administration of melanocortin agonists compared to control groups. These results suggest that the MC4R in the hypothalamus plays a role in the central regulation of erectile function independent of the peripheral vascular system.<br \/>\nResearch in this area continues with the aim of better understanding the neurobiological mechanisms responsible for this response.<br \/>\n<em>Source: Wessells H. et al., Journal of Urology (2000)<\/em><br \/>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-757679346\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Technical Specifications<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Parameter<\/strong><\/td>\n<td><strong>Value<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Chemical name<\/strong><\/td>\n<td>Bremelanotide (PT-141)<\/td>\n<\/tr>\n<tr>\n<td><strong>Type<\/strong><\/td>\n<td>Cyclic heptapeptide<\/td>\n<\/tr>\n<tr>\n<td><strong>Origin<\/strong><\/td>\n<td>Derived from Melanotan-2 (a metabolite resulting from enzymatic cleavage)<\/td>\n<\/tr>\n<tr>\n<td><strong>Molecular weight<\/strong><\/td>\n<td>1,025.2 Da<\/td>\n<\/tr>\n<tr>\n<td><strong>CAS Number<\/strong><\/td>\n<td>189691-06-3<\/td>\n<\/tr>\n<tr>\n<td><strong>Form<\/strong><\/td>\n<td>Lyophilized (freeze-dried) white powder<\/td>\n<\/tr>\n<tr>\n<td><strong>Contents per package<\/strong><\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td><strong>Purity<\/strong><\/td>\n<td>\u2265 98% (HPLC-verified)<\/td>\n<\/tr>\n<tr>\n<td><strong>Recommended storage conditions<\/strong><\/td>\n<td>\u221220 \u00b0C, protected from light and moisture<\/td>\n<\/tr>\n<tr>\n<td><strong>Stability (lyophilisate)<\/strong><\/td>\n<td>Up to 24 months at \u221220 \u00b0C<\/td>\n<\/tr>\n<tr>\n<td><strong>Stability (reconstituted)<\/strong><\/td>\n<td>Up to 28 days at 4 \u00b0C, up to 6 months at \u221220 \u00b0C<\/td>\n<\/tr>\n<tr>\n<td><strong>Intended Use<\/strong><\/td>\n<td>For scientific research purposes only<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1124400576\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2>Frequently Asked Questions About PT-141 (Bremelanotide)<\/h2>\n<div class=\"accordion\">\n\t<div id=\"accordion-1958502765\" class=\"accordion-item\">\n\t\t<a id=\"accordion-1958502765-label\" class=\"accordion-title plain\" href=\"#accordion-item-what-is-pt-141,-and-how-is-it-related-to-melanotan-2?\" aria-expanded=\"false\" aria-controls=\"accordion-1958502765-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>What is PT-141, and how is it related to Melanotan-2?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-1958502765-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-1958502765-label\">\n\t\t\t\n<\/strong>PT-141 (bremelanotide) is a cyclic heptapeptide derived from Melanotan-2. It is formed by enzymatic cleavage of the N-terminal portion of MT-2, which alters its receptor-binding profile. While MT-2 activates several melanocortin receptors, including MC1R (pigmentation), PT-141 exhibits greater selectivity for MC4R\u2014a receptor expressed in brain regions studied in relation to sexual function. This means that, when used for research purposes, PT-141 does not cause significant melanogenesis.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-542285584\" class=\"accordion-item\">\n\t\t<a id=\"accordion-542285584-label\" class=\"accordion-title plain\" href=\"#accordion-item-why-is-pt-141-of-research-interest-in-connection-with-vyleesi\u00ae?\" aria-expanded=\"false\" aria-controls=\"accordion-542285584-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>Why is PT-141 of research interest in connection with Vyleesi\u00ae?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-542285584-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-542285584-label\">\n\t\t\t\n<\/strong>In 2019, the FDA approved bremelanotide, marketed under the brand name Vyleesi\u00ae, for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. This is the first FDA approval for this indication with a central (rather than vascular) mechanism of action. This molecule is of particular interest to the scientific community precisely because it demonstrates the validity of MC4R as a therapeutic target in the field of sexual neurophysiology.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-1225472341\" class=\"accordion-item\">\n\t\t<a id=\"accordion-1225472341-label\" class=\"accordion-title plain\" href=\"#accordion-item-how-does-the-mechanism-of-action-of-pt-141-differ-from-that-of-pde5-inhibitors?\" aria-expanded=\"false\" aria-controls=\"accordion-1225472341-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>How does the mechanism of action of PT-141 differ from that of PDE5 inhibitors?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-1225472341-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-1225472341-label\">\n\t\t\t\n<\/strong>PDE5 inhibitors (e.g., sildenafil) act peripherally\u2014they dilate blood vessels in the genital organs by inhibiting phosphodiesterase 5 and increasing cGMP levels. PT-141 acts centrally\u2014it activates MC4R receptors in the hypothalamus and limbic system, which are brain regions involved in the regulation of sexual motivation. These two mechanisms are independent of one another, and preclinical research is investigating their potential complementarity.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-1318648515\" class=\"accordion-item\">\n\t\t<a id=\"accordion-1318648515-label\" class=\"accordion-title plain\" href=\"#accordion-item-what-is-the-purity-of-the-pt-141-sold-on-jacked.sk?\" aria-expanded=\"false\" aria-controls=\"accordion-1318648515-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>What is the purity of the PT-141 sold on jacked.sk?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-1318648515-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-1318648515-label\">\n\t\t\t\n<\/strong>PT-141 from jacked.sk has a purity of \u226598%, verified by HPLC (High-Performance Liquid Chromatography). Each batch is tested before shipment. A Certificate of Analysis (COA) is available upon request.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-3035156947\" class=\"accordion-item\">\n\t\t<a id=\"accordion-3035156947-label\" class=\"accordion-title plain\" href=\"#accordion-item-how-should-freeze-dried-pt-141-be-stored?\" aria-expanded=\"false\" aria-controls=\"accordion-3035156947-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>How should freeze-dried PT-141 be stored?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-3035156947-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-3035156947-label\">\n\t\t\t\n<\/strong>Store unopened packages at \u221220 \u00b0C, protected from light and moisture. After reconstitution with bacteriostatic water, store at 4 \u00b0C (for up to 28 days) or refreeze at \u221220 \u00b0C (for up to 6 months). We recommend avoiding repeated thawing and refreezing, which may reduce the stability of the peptide.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n\t<div id=\"accordion-2667860574\" class=\"accordion-item\">\n\t\t<a id=\"accordion-2667860574-label\" class=\"accordion-title plain\" href=\"#accordion-item-is-pt-141-legal-in-slovakia?\" aria-expanded=\"false\" aria-controls=\"accordion-2667860574-content\">\n\t\t\t<button class=\"toggle\" aria-label=\"Toggle\"><i class=\"icon-angle-down\" aria-hidden=\"true\"><\/i><\/button>\n\t\t\t<span>Is PT-141 legal in Slovakia?<\/span>\n\t\t<\/a>\n\t\t<div id=\"accordion-2667860574-content\" class=\"accordion-inner\" aria-labelledby=\"accordion-2667860574-label\">\n\t\t\t\n<\/strong>PT-141 (bremelanotide) is not listed as a controlled substance or a prohibited drug in the EU. In Slovakia, its purchase and possession for scientific research purposes are legal. Sales are intended exclusively for scientists and researchers. Jacked.sk sells PT-141 solely for scientific and research purposes, not for human use.<br \/>\n\t\t<\/div>\n\t<\/div>\n\t\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-780095515\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t<div class=\"is-border\"\n\t\tstyle=\"border-color:#fe5000;border-width:1px 1px 1px 1px;\">\n\t<\/div>\n\t\t\t\n<h4>\u26a0\ufe0f Warning \u2013 Intended exclusively for research purposes<\/h4>\n<p><strong>All products sold on jacked.sk are intended EXCLUSIVELY for scientific research purposes.<\/strong>  They are not intended for use as a medicine, drug, dietary supplement, or cosmetic product, nor for human or veterinary use. The results cited in the descriptions are based on preclinical studies (in vitro, animal models) and cannot be automatically extrapolated to human use. Sale restricted to individuals over the age of 18. By purchasing this product, the customer confirms that they are a professional researcher and will use the product solely in accordance with applicable laws.<br \/>\n\t\t<\/div>\n\t\t\t\t\n<style>\n#col-780095515 > .col-inner {\n  padding: 0.5rem 0.5rem 0.5rem 0.5rem;\n}\n<\/style>\n\t<\/div>\n\n\t\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PT-141 (bremelanotide) is a cyclic heptapeptide derived from Melanotan-2 that selectively activates the MC4R receptor. Unlike PDE5 inhibitors, <strong>it does not act on the vascular system, but rather centrally<\/strong> \u2014in the hypothalamus and limbic system. This is precisely what makes it a subject of research in areas where peripheral mechanisms are insufficient.  <\/p>\n<ul>\n<li>Purity <strong>\u2265 98%<\/strong> \u2013 Each batch verified by HPLC; COA available upon request<\/li>\n<li>10 mg of lyophilized powder, stable for 24 months at \u221220 \u00b0C<\/li>\n<li>Shipped within 48 hours<\/li>\n<\/ul>\n","protected":false},"featured_media":3017,"template":"","meta":[],"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-3138","product","type-product","status-publish","has-post-thumbnail","product_cat-research-on-sun-exposure-and-sexual-health","first","instock","sale","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product\/3138","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/media\/3017"}],"wp:attachment":[{"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/media?parent=3138"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_brand?post=3138"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_cat?post=3138"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/dev.jacked.sk\/en\/wp-json\/wp\/v2\/product_tag?post=3138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}