{"id":1176,"date":"2018-06-13T08:37:11","date_gmt":"2018-06-13T06:37:11","guid":{"rendered":"https:\/\/jacked.sk\/obchod\/melanotan-2-2\/"},"modified":"2026-08-21T14:33:02","modified_gmt":"2026-08-21T12:33:02","slug":"melanotan-2-10mg","status":"publish","type":"product","link":"https:\/\/dev.jacked.sk\/en\/research-on-sun-exposure-and-sexual-health\/melanotan-2-10mg\/","title":{"rendered":"MELANOTAN-2 10 mg"},"content":{"rendered":"
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Melanotan-2 10 mg \u2013 Synthetic \u03b1-MSH Analog for Pigmentation Research<\/h1>\n

\u26a0\ufe0f Warning:<\/strong> Melanotan-2 is intended exclusively for scientific and research purposes. It is not intended for human use as a medication, dietary supplement, or cosmetic product. Melanotan-2 is not approved as a drug in the European Union or by the FDA.<\/strong> Sale exclusively to persons over the age of 18.
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What is Melanotan-2?<\/h2>\n

Melanotan-2 (MT-2) is a cyclic synthetic heptapeptide<\/strong> \u2014an analog of the natural hormone \u03b1-MSH (alpha-melanocyte-stimulating hormone). \u03b1-MSH is an endogenous hormone produced by the pituitary gland that plays a key role in regulating skin pigmentation, energy metabolism, and sexual function through the activation of melanocortin receptors.
\nMelanotan-2 was originally developed at the University of Arizona<\/strong> in the 1980s and 1990s as a research tool for studying melanocortin signaling. The development was motivated by research into the potential protection of the skin against UV radiation through the stimulation of melanogenesis.
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Amino Acid Sequence and Structure<\/h3>\n

Melanotan-2 amino acid sequence:Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH\u2082<\/strong>
\nThe cyclic structure of the peptide (a lactam bond between Asp and Lys) increases its resistance to enzymatic degradation compared to linear \u03b1-MSH, which prolongs its half-life. The substitutions Met\u2192Nle (norleucine) and Phe\u2192D-Phe increase the affinity for melanocortin receptors.
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Melanotan-2 is not an approved drug \u2013 research context<\/h3>\n

Melanotan-2 has never been approved by<\/strong> a regulatory agency (the EMA, FDA, or any other) as a drug. The European Medicines Agency (EMA) has issued several warnings regarding its illegal sale outside of a research context. All Melanotan-2 products on jacked.sk are intended exclusively for scientifically trained researchers working under regulated laboratory conditions.
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The Melanocortin System\u2014The Basis for MT-2 Research<\/h2>\n

Melanotan-2 acts as an agonist of melanocortin receptors<\/strong> (MC receptors). There are five types of MC receptors (MC1R\u2013MC5R), and MT-2 has the highest affinity for MC1R and MC4R:
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MC1R \u2013 Research on Pigmentation and Melanogenesis<\/h3>\n

MC1R<\/strong> (Melanocortin 1 Receptor) is expressed primarily on melanocytes<\/strong> \u2014the pigment-producing cells of the skin. Its activation leads to: – Stimulation of melanogenesis\u2014the synthesis of melanin pigment (preferentially eumelanin, black\/brown) – Activation of the enzyme tyrosinase (a key step in melanin biosynthesis)- In vitro studies suggest a potential photoprotective role of eumelanin against UV-induced DNA damage
\nResearch on MC1R activation is relevant to dermatology, skin oncology, and photobiology.
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MC4R \u2013 Research on Sexual Function and the Regulation of Food Intake<\/h3>\n

MC4R<\/strong> (Melanocortin 4 Receptor) is expressed primarily in the central nervous system<\/strong> (hypothalamus). It is involved in: – Regulation of sexual arousal and erectile function (research in animal models and clinical studies) – Regulation of food intake and energy expenditure (MC4R mutations are associated with monogenic obesity in human populations)\u2014Research on MC4R agonists is the subject of intense interest in the fields of sexual medicine and metabolic research
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Areas of Preclinical Research on Melanotan-2<\/h2>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Research on Melanogenesis and Photoprotection (in vitro)<\/h3>\n

Studies on cultured melanocytes and mouse models show that MT-2 administration leads to a statistically significant increase in eumelanin synthesis. In some experiments using a mouse model (C57BL\/6 mice), darkening of the fur<\/strong> was observed following systemic administration of MT-2, which serves as an in vivo marker of MC1R activation.
\nThe research hypothesis regarding the photoprotective effect of increased eumelanin (potential protection against UV-induced carcinogenesis) is the subject of a long-term study; however, clinical confirmation of this effect is not available.
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Research on Sexual Function<\/h3>\n

Preclinical studies in animal models have documented the pro-erectile effects of Melanotan-2 through MC4R agonism in the CNS. These results led to the development of a more selective MC4R agonist\u2014 PT-141 (Bremelanotide)<\/strong> \u2014which was later tested in clinical trials.
\nBremelanotide (derived from MT-2) received FDA approval in 2019 under the brand name Vyleesi\u00ae for the treatment of hypoactive sexual desire disorder in premenopausal women. This approval applies exclusively to Bremelanotide\/PT-141, not to Melanotan-2<\/strong>.
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Research on Weight Control<\/h3>\n

MC4R activation in the hypothalamus (arcuate nucleus) modulates satiety and energy expenditure signaling. In preclinical studies, chronic administration of MT-2 was associated with a reduction in food intake and body weight. This mechanism is the subject of research in the context of obesity and metabolic syndrome.
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Melanotan-2 vs. PT-141 (Bremelanotide)<\/h2>\n\n\n\n\n\n\n\n\n\n
Property<\/strong><\/td>\nMelanotan-2 (MT-2)<\/strong><\/td>\nPT-141 (Bremelanotide)<\/strong><\/td>\n<\/tr>\n
Peptide Type<\/td>\nCyclic heptapeptide<\/td>\nCyclic heptapeptide<\/td>\n<\/tr>\n
Receptor Profile<\/td>\nMC1R + MC4R (+ MC3R)<\/td>\nPrimarily MC4R<\/td>\n<\/tr>\n
Effect on Pigmentation<\/td>\nYES (MC1R)<\/td>\nMinimal<\/td>\n<\/tr>\n
Research on Sexual Function<\/td>\nYES (MC4R)<\/td>\nYES \u2013 primary interest<\/td>\n<\/tr>\n
Regulatory Status<\/td>\nNot approved (EU\/FDA)<\/td>\nFDA-approved (Vyleesi\u00ae, 2019)<\/td>\n<\/tr>\n
MW<\/td>\n1,024 Da<\/td>\n1,025 Da<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

PT-141 is a metabolic derivative of Melanotan-2 with higher selectivity for MC4R, while MT-2 has a broader melanocortin profile with significant activity at MC1R.
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Technical Specifications<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/strong><\/td>\nValue<\/strong><\/td>\n<\/tr>\n
Chemical Name<\/strong><\/td>\nMelanotan-2 (MT-2)<\/td>\n<\/tr>\n
IUPAC \/ Sequence<\/strong><\/td>\nAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH\u2082<\/td>\n<\/tr>\n
Molecular weight<\/strong><\/td>\n1,024.2 Da<\/td>\n<\/tr>\n
CAS Number<\/strong><\/td>\n121062-08-6<\/td>\n<\/tr>\n
Contents per package<\/strong><\/td>\n10 mg<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u2265 98% (HPLC-verified)<\/td>\n<\/tr>\n
Product Form<\/strong><\/td>\nFreeze-dried white powder<\/td>\n<\/tr>\n
Recommended storage conditions<\/strong><\/td>\n\u221220 \u00b0C, protected from light and moisture<\/td>\n<\/tr>\n
Stability (lyophilisate)<\/strong><\/td>\nUp to 24 months at \u221220 \u00b0C<\/td>\n<\/tr>\n
Stability (reconstituted)<\/strong><\/td>\nUp to 28 days at 4 \u00b0C<\/td>\n<\/tr>\n
Regulatory Status<\/strong><\/td>\nUnapproved drug (EU\/FDA); for research purposes only<\/td>\n<\/tr>\n
Intended Use<\/strong><\/td>\nFor scientific research purposes only<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t
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Frequently Asked Questions About Melanotan-2<\/h2>\n
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